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Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors

OBJECTIVE: Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social...

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Autores principales: Eisenberg, Yuval, Dugas, Lara R., Akbar, Arfana, Reddivari, Bharathi, Layden, Brian T., Barengolts, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754076/
https://www.ncbi.nlm.nih.gov/pubmed/29300770
http://dx.doi.org/10.1371/journal.pone.0190301
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author Eisenberg, Yuval
Dugas, Lara R.
Akbar, Arfana
Reddivari, Bharathi
Layden, Brian T.
Barengolts, Elena
author_facet Eisenberg, Yuval
Dugas, Lara R.
Akbar, Arfana
Reddivari, Bharathi
Layden, Brian T.
Barengolts, Elena
author_sort Eisenberg, Yuval
collection PubMed
description OBJECTIVE: Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social and behavioral factors. DESIGN AND METHODS: A total of 92 obese or overweight, African American, male subjects were enrolled in the study. Biometric and biochemical data were collected including oral glucose tolerance testing and urinary OT (measured by ELISA). Subjects also completed questionnaires on social and lifestyle factors. RESULTS: OT levels were found to be significantly lower in subjects with type 2 diabetes mellitus (T2DM) compared to normal glucose tolerance (p<0.05). When stratified by OT tertiles, subjects with higher OT had lower weight, body mass index (BMI) and hemoglobin A1c, but higher eGFR which remained significant after BMI adjustment. The highest OT tertile also had more smokers and more users of psychiatric medications. A stepwise ordered logistic regression supported these findings and could account for 21% of the variation in OT categories (pseudoR(2) = 0.21). CONCLUSIONS: In this unique population, OT was found lower in subjects with diabetes but higher with better renal function, cigarette smoking and use of psychiatric medications. Future studies are needed to confirm these findings and examine the potential therapeutic role of OT.
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spelling pubmed-57540762018-01-26 Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors Eisenberg, Yuval Dugas, Lara R. Akbar, Arfana Reddivari, Bharathi Layden, Brian T. Barengolts, Elena PLoS One Research Article OBJECTIVE: Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social and behavioral factors. DESIGN AND METHODS: A total of 92 obese or overweight, African American, male subjects were enrolled in the study. Biometric and biochemical data were collected including oral glucose tolerance testing and urinary OT (measured by ELISA). Subjects also completed questionnaires on social and lifestyle factors. RESULTS: OT levels were found to be significantly lower in subjects with type 2 diabetes mellitus (T2DM) compared to normal glucose tolerance (p<0.05). When stratified by OT tertiles, subjects with higher OT had lower weight, body mass index (BMI) and hemoglobin A1c, but higher eGFR which remained significant after BMI adjustment. The highest OT tertile also had more smokers and more users of psychiatric medications. A stepwise ordered logistic regression supported these findings and could account for 21% of the variation in OT categories (pseudoR(2) = 0.21). CONCLUSIONS: In this unique population, OT was found lower in subjects with diabetes but higher with better renal function, cigarette smoking and use of psychiatric medications. Future studies are needed to confirm these findings and examine the potential therapeutic role of OT. Public Library of Science 2018-01-04 /pmc/articles/PMC5754076/ /pubmed/29300770 http://dx.doi.org/10.1371/journal.pone.0190301 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Eisenberg, Yuval
Dugas, Lara R.
Akbar, Arfana
Reddivari, Bharathi
Layden, Brian T.
Barengolts, Elena
Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors
title Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors
title_full Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors
title_fullStr Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors
title_full_unstemmed Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors
title_short Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors
title_sort oxytocin is lower in african american men with diabetes and associates with psycho-social and metabolic health factors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754076/
https://www.ncbi.nlm.nih.gov/pubmed/29300770
http://dx.doi.org/10.1371/journal.pone.0190301
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