Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab

Pulmonary pleomorphic carcinoma has been shown to respond remarkably to PD‐1 inhibitors; however, the biomarkers for this therapy have not been fully proven. We report a case of pulmonary pleomorphic carcinoma with overexpressed PD‐L1, in which a complete response to nivolumab was sustained for >...

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Autores principales: Okamura, Kazuaki, Fukuda, Yuichi, Soda, Hiroshi, Ogawara, Daiki, Iwasaki, Keisuke, Fuchi, Shinichiro, Suyama, Takayuki, Yoshida, Masataka, Harada, Tatsuhiko, Fukuda, Minoru, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754285/
https://www.ncbi.nlm.nih.gov/pubmed/29131510
http://dx.doi.org/10.1111/1759-7714.12557
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author Okamura, Kazuaki
Fukuda, Yuichi
Soda, Hiroshi
Ogawara, Daiki
Iwasaki, Keisuke
Fuchi, Shinichiro
Suyama, Takayuki
Yoshida, Masataka
Harada, Tatsuhiko
Fukuda, Minoru
Mukae, Hiroshi
author_facet Okamura, Kazuaki
Fukuda, Yuichi
Soda, Hiroshi
Ogawara, Daiki
Iwasaki, Keisuke
Fuchi, Shinichiro
Suyama, Takayuki
Yoshida, Masataka
Harada, Tatsuhiko
Fukuda, Minoru
Mukae, Hiroshi
author_sort Okamura, Kazuaki
collection PubMed
description Pulmonary pleomorphic carcinoma has been shown to respond remarkably to PD‐1 inhibitors; however, the biomarkers for this therapy have not been fully proven. We report a case of pulmonary pleomorphic carcinoma with overexpressed PD‐L1, in which a complete response to nivolumab was sustained for >14 months. Immunohistochemical analysis revealed few PD‐1(+) immune cells and regulatory T cells in the tumor, in addition to predominant infiltration of CD8(+) cells and macrophages. Our findings suggest that the presence of a small number of PD‐1(+) immune cells and regulatory T cells should be investigated as candidate therapeutic biomarkers.
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spelling pubmed-57542852018-01-09 Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab Okamura, Kazuaki Fukuda, Yuichi Soda, Hiroshi Ogawara, Daiki Iwasaki, Keisuke Fuchi, Shinichiro Suyama, Takayuki Yoshida, Masataka Harada, Tatsuhiko Fukuda, Minoru Mukae, Hiroshi Thorac Cancer Case Reports Pulmonary pleomorphic carcinoma has been shown to respond remarkably to PD‐1 inhibitors; however, the biomarkers for this therapy have not been fully proven. We report a case of pulmonary pleomorphic carcinoma with overexpressed PD‐L1, in which a complete response to nivolumab was sustained for >14 months. Immunohistochemical analysis revealed few PD‐1(+) immune cells and regulatory T cells in the tumor, in addition to predominant infiltration of CD8(+) cells and macrophages. Our findings suggest that the presence of a small number of PD‐1(+) immune cells and regulatory T cells should be investigated as candidate therapeutic biomarkers. John Wiley & Sons Australia, Ltd 2017-11-13 2018-01 /pmc/articles/PMC5754285/ /pubmed/29131510 http://dx.doi.org/10.1111/1759-7714.12557 Text en © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Okamura, Kazuaki
Fukuda, Yuichi
Soda, Hiroshi
Ogawara, Daiki
Iwasaki, Keisuke
Fuchi, Shinichiro
Suyama, Takayuki
Yoshida, Masataka
Harada, Tatsuhiko
Fukuda, Minoru
Mukae, Hiroshi
Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab
title Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab
title_full Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab
title_fullStr Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab
title_full_unstemmed Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab
title_short Pulmonary pleomorphic carcinoma with few PD‐1‐positive immune cells and regulatory T cells that showed a complete response to nivolumab
title_sort pulmonary pleomorphic carcinoma with few pd‐1‐positive immune cells and regulatory t cells that showed a complete response to nivolumab
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754285/
https://www.ncbi.nlm.nih.gov/pubmed/29131510
http://dx.doi.org/10.1111/1759-7714.12557
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