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Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report
Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754307/ https://www.ncbi.nlm.nih.gov/pubmed/29090842 http://dx.doi.org/10.1111/1759-7714.12554 |
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author | Sakai, Hiroki Saji, Hisashi Kimura, Hiroyuki Tsuda, Masataka Wakiyama, Yoichi Miyazawa, Tomoyuki Marushima, Hideki Kojima, Koji Hoshikawa, Masahiro Takagi, Masayuki Nakamura, Haruhiko |
author_facet | Sakai, Hiroki Saji, Hisashi Kimura, Hiroyuki Tsuda, Masataka Wakiyama, Yoichi Miyazawa, Tomoyuki Marushima, Hideki Kojima, Koji Hoshikawa, Masahiro Takagi, Masayuki Nakamura, Haruhiko |
author_sort | Sakai, Hiroki |
collection | PubMed |
description | Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors. |
format | Online Article Text |
id | pubmed-5754307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57543072018-01-09 Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report Sakai, Hiroki Saji, Hisashi Kimura, Hiroyuki Tsuda, Masataka Wakiyama, Yoichi Miyazawa, Tomoyuki Marushima, Hideki Kojima, Koji Hoshikawa, Masahiro Takagi, Masayuki Nakamura, Haruhiko Thorac Cancer Case Reports Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors. John Wiley & Sons Australia, Ltd 2017-11-01 2018-01 /pmc/articles/PMC5754307/ /pubmed/29090842 http://dx.doi.org/10.1111/1759-7714.12554 Text en © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Sakai, Hiroki Saji, Hisashi Kimura, Hiroyuki Tsuda, Masataka Wakiyama, Yoichi Miyazawa, Tomoyuki Marushima, Hideki Kojima, Koji Hoshikawa, Masahiro Takagi, Masayuki Nakamura, Haruhiko Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report |
title | Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report |
title_full | Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report |
title_fullStr | Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report |
title_full_unstemmed | Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report |
title_short | Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report |
title_sort | different egfr gene mutations in two patients with synchronous multiple lung cancers: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754307/ https://www.ncbi.nlm.nih.gov/pubmed/29090842 http://dx.doi.org/10.1111/1759-7714.12554 |
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