Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling

Long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to play crucial regulatory roles in many types of cancer. However, the biological function of long ncRNA (lncRNA) SNHG20 in ovarian cancer is still unclear. In the present study, we found that lncRNA SNHG20 was signi...

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Autores principales: He, Shanyang, Zhao, Yunhe, Wang, Xiaoping, Deng, Yalan, Wan, Zhiyong, Yao, Shuzhong, Shen, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754315/
https://www.ncbi.nlm.nih.gov/pubmed/29101241
http://dx.doi.org/10.1042/BSR20170681
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author He, Shanyang
Zhao, Yunhe
Wang, Xiaoping
Deng, Yalan
Wan, Zhiyong
Yao, Shuzhong
Shen, Hongwei
author_facet He, Shanyang
Zhao, Yunhe
Wang, Xiaoping
Deng, Yalan
Wan, Zhiyong
Yao, Shuzhong
Shen, Hongwei
author_sort He, Shanyang
collection PubMed
description Long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to play crucial regulatory roles in many types of cancer. However, the biological function of long ncRNA (lncRNA) SNHG20 in ovarian cancer is still unclear. In the present study, we found that lncRNA SNHG20 was significantly increased in ovarian cancer. In addition, lncRNA SNHG20 knockdown suppressed the ovarian cancer progression, whereas overexpression of SNHG20 showed the opposite effects. Moreover, our results also revealed that lncRNA SNHG20 knockdown inhibited Wnt/β-catenin signaling activity by suppressing β-catenin expression and reversing the downstream target gene expression. Taken together, lncRNA SNHG20 plays an pivotal role in ovarian cancer progression by regulating Wnt/β-catenin signaling.
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spelling pubmed-57543152018-01-19 Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling He, Shanyang Zhao, Yunhe Wang, Xiaoping Deng, Yalan Wan, Zhiyong Yao, Shuzhong Shen, Hongwei Biosci Rep Research Articles Long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to play crucial regulatory roles in many types of cancer. However, the biological function of long ncRNA (lncRNA) SNHG20 in ovarian cancer is still unclear. In the present study, we found that lncRNA SNHG20 was significantly increased in ovarian cancer. In addition, lncRNA SNHG20 knockdown suppressed the ovarian cancer progression, whereas overexpression of SNHG20 showed the opposite effects. Moreover, our results also revealed that lncRNA SNHG20 knockdown inhibited Wnt/β-catenin signaling activity by suppressing β-catenin expression and reversing the downstream target gene expression. Taken together, lncRNA SNHG20 plays an pivotal role in ovarian cancer progression by regulating Wnt/β-catenin signaling. Portland Press Ltd. 2018-01-05 /pmc/articles/PMC5754315/ /pubmed/29101241 http://dx.doi.org/10.1042/BSR20170681 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
He, Shanyang
Zhao, Yunhe
Wang, Xiaoping
Deng, Yalan
Wan, Zhiyong
Yao, Shuzhong
Shen, Hongwei
Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling
title Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling
title_full Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling
title_fullStr Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling
title_full_unstemmed Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling
title_short Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling
title_sort up-regulation of long non-coding rna snhg20 promotes ovarian cancer progression via wnt/β-catenin signaling
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754315/
https://www.ncbi.nlm.nih.gov/pubmed/29101241
http://dx.doi.org/10.1042/BSR20170681
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