Complete Genome Sequences of Two Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated in Guiyang, China

We identified the genome sequences of two Mycobacterium tuberculosis isolates. They were resistant to rifampin and isoniazid, as determined by the agar proportion method, but were susceptible to isoniazid, as determined by the DNA array method. The genome sequences showed that a katG deletion led to...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Zhenghong, Ou, Weizheng, Fan, Xiangyu, Cui, Guzhen, Wang, Qiong, Li, Qiang, Sun, Rong, Wu, Xiaojuan, Qin, Wan, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754478/
https://www.ncbi.nlm.nih.gov/pubmed/29301898
http://dx.doi.org/10.1128/genomeA.01257-17
Descripción
Sumario:We identified the genome sequences of two Mycobacterium tuberculosis isolates. They were resistant to rifampin and isoniazid, as determined by the agar proportion method, but were susceptible to isoniazid, as determined by the DNA array method. The genome sequences showed that a katG deletion led to the false diagnosis of isoniazid resistance by DNA array.

Ejemplares similares