Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers

DNA methylation at promoters is an important determinant of gene expression. Earlier studies suggested that the insulin gene promoter is uniquely unmethylated in insulin-expressing pancreatic β-cells, providing a classic example of this paradigm. Here we show that islet cells expressing insulin, glu...

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Detalles Bibliográficos
Autores principales: Neiman, Daniel, Moss, Joshua, Hecht, Merav, Magenheim, Judith, Piyanzin, Sheina, Shapiro, A. M. James, de Koning, Eelco J. P., Razin, Aharon, Cedar, Howard, Shemer, Ruth, Dor, Yuval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754795/
https://www.ncbi.nlm.nih.gov/pubmed/29203669
http://dx.doi.org/10.1073/pnas.1713736114

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