Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

BACKGROUND: The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations in genes hitherto unknown to belong to the pa...

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Detalles Bibliográficos
Autores principales: Kundu, Snehangshu, Ali, Muhammad Akhtar, Handin, Niklas, Padhan, Narendra, Larsson, Jimmy, Karoutsou, Maria, Ban, Kenneth, Wiśniewski, Jacek R., Artursson, Per, He, Liqun, Hellström, Mats, Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755028/
https://www.ncbi.nlm.nih.gov/pubmed/29301589
http://dx.doi.org/10.1186/s13073-017-0511-4

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