Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

BACKGROUND: Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or N155H, representing three distinct resistance pathways. The mechanisms...

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Detalles Bibliográficos
Autores principales: Fun, Axel, Leitner, Thomas, Vandekerckhove, Linos, Däumer, Martin, Thielen, Alexander, Buchholz, Bernd, Hoepelman, Andy I. M., Gisolf, Elizabeth H., Schipper, Pauline J., Wensing, Annemarie M. J., Nijhuis, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755036/
https://www.ncbi.nlm.nih.gov/pubmed/29304821
http://dx.doi.org/10.1186/s12977-017-0384-z

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