Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BACKGROUND: Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and f...

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Detalles Bibliográficos
Autores principales: Gainetdinov, Ildar V., Skvortsova, Yulia V., Kondratieva, Sofia A., Klimov, Alexey, Tryakin, Alexey A., Azhikina, Tatyana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755174/
https://www.ncbi.nlm.nih.gov/pubmed/29301509
http://dx.doi.org/10.1186/s12885-017-3945-6

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