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Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) dat...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755234/ https://www.ncbi.nlm.nih.gov/pubmed/29344230 http://dx.doi.org/10.3892/ol.2017.7228 |
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author | Lu, Gaixia Fu, Da Jia, Chengyou Chai, Li Han, Yang Liu, Jin Wu, Tingmiao Xie, Ruting Chang, Zhengyan Yang, Huiqiong Luo, Pei Lv, Zhongwei Yu, Fei Zhong, Xiaojun Ma, Yushui |
author_facet | Lu, Gaixia Fu, Da Jia, Chengyou Chai, Li Han, Yang Liu, Jin Wu, Tingmiao Xie, Ruting Chang, Zhengyan Yang, Huiqiong Luo, Pei Lv, Zhongwei Yu, Fei Zhong, Xiaojun Ma, Yushui |
author_sort | Lu, Gaixia |
collection | PubMed |
description | Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and assessed miR-105-1 expression in 32 normal lung and 142 non-small cell lung cancer (NSCLC) tissue samples using reverse transcription-quantitative polymerase chain reaction. Survival data were calculated using Kaplan-Meier curves and a log-rank test. The stepwise forward Cox regression model was performed for univariate and multivariate analyses of independent predictor of overall survival (OS) of patients. The data on in silico and tissue microarray analyses of miRNA expression revealed reduced miR-105-1 expression in different types of human cancer, particularly in NSCLC. The level of miR-105-1 expression was confirmed to be downregulated in NSCLC tissues compared with that in normal lung tissues. Reduced miR-105-1 expression was associated with larger tumor size as well as poor OS and disease-free survival (DFS) of patients. Multivariate survival analysis demonstrated that reduced miR-105-1 expression and tumor size were independent predictors for OS of NSCLC patients. In conclusion, reduced miR-105-1 expression in NSCLC tissues is associated with poor OS and DFS of NSCLC patients. |
format | Online Article Text |
id | pubmed-5755234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-57552342018-01-17 Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer Lu, Gaixia Fu, Da Jia, Chengyou Chai, Li Han, Yang Liu, Jin Wu, Tingmiao Xie, Ruting Chang, Zhengyan Yang, Huiqiong Luo, Pei Lv, Zhongwei Yu, Fei Zhong, Xiaojun Ma, Yushui Oncol Lett Articles Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and assessed miR-105-1 expression in 32 normal lung and 142 non-small cell lung cancer (NSCLC) tissue samples using reverse transcription-quantitative polymerase chain reaction. Survival data were calculated using Kaplan-Meier curves and a log-rank test. The stepwise forward Cox regression model was performed for univariate and multivariate analyses of independent predictor of overall survival (OS) of patients. The data on in silico and tissue microarray analyses of miRNA expression revealed reduced miR-105-1 expression in different types of human cancer, particularly in NSCLC. The level of miR-105-1 expression was confirmed to be downregulated in NSCLC tissues compared with that in normal lung tissues. Reduced miR-105-1 expression was associated with larger tumor size as well as poor OS and disease-free survival (DFS) of patients. Multivariate survival analysis demonstrated that reduced miR-105-1 expression and tumor size were independent predictors for OS of NSCLC patients. In conclusion, reduced miR-105-1 expression in NSCLC tissues is associated with poor OS and DFS of NSCLC patients. D.A. Spandidos 2017-12 2017-10-19 /pmc/articles/PMC5755234/ /pubmed/29344230 http://dx.doi.org/10.3892/ol.2017.7228 Text en Copyright: © Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Lu, Gaixia Fu, Da Jia, Chengyou Chai, Li Han, Yang Liu, Jin Wu, Tingmiao Xie, Ruting Chang, Zhengyan Yang, Huiqiong Luo, Pei Lv, Zhongwei Yu, Fei Zhong, Xiaojun Ma, Yushui Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
title | Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
title_full | Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
title_fullStr | Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
title_full_unstemmed | Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
title_short | Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
title_sort | reduced mir-105-1 levels are associated with poor survival of patients with non-small cell lung cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755234/ https://www.ncbi.nlm.nih.gov/pubmed/29344230 http://dx.doi.org/10.3892/ol.2017.7228 |
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