Cargando…

Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer

Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) dat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Gaixia, Fu, Da, Jia, Chengyou, Chai, Li, Han, Yang, Liu, Jin, Wu, Tingmiao, Xie, Ruting, Chang, Zhengyan, Yang, Huiqiong, Luo, Pei, Lv, Zhongwei, Yu, Fei, Zhong, Xiaojun, Ma, Yushui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755234/
https://www.ncbi.nlm.nih.gov/pubmed/29344230
http://dx.doi.org/10.3892/ol.2017.7228
_version_ 1783290560653557760
author Lu, Gaixia
Fu, Da
Jia, Chengyou
Chai, Li
Han, Yang
Liu, Jin
Wu, Tingmiao
Xie, Ruting
Chang, Zhengyan
Yang, Huiqiong
Luo, Pei
Lv, Zhongwei
Yu, Fei
Zhong, Xiaojun
Ma, Yushui
author_facet Lu, Gaixia
Fu, Da
Jia, Chengyou
Chai, Li
Han, Yang
Liu, Jin
Wu, Tingmiao
Xie, Ruting
Chang, Zhengyan
Yang, Huiqiong
Luo, Pei
Lv, Zhongwei
Yu, Fei
Zhong, Xiaojun
Ma, Yushui
author_sort Lu, Gaixia
collection PubMed
description Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and assessed miR-105-1 expression in 32 normal lung and 142 non-small cell lung cancer (NSCLC) tissue samples using reverse transcription-quantitative polymerase chain reaction. Survival data were calculated using Kaplan-Meier curves and a log-rank test. The stepwise forward Cox regression model was performed for univariate and multivariate analyses of independent predictor of overall survival (OS) of patients. The data on in silico and tissue microarray analyses of miRNA expression revealed reduced miR-105-1 expression in different types of human cancer, particularly in NSCLC. The level of miR-105-1 expression was confirmed to be downregulated in NSCLC tissues compared with that in normal lung tissues. Reduced miR-105-1 expression was associated with larger tumor size as well as poor OS and disease-free survival (DFS) of patients. Multivariate survival analysis demonstrated that reduced miR-105-1 expression and tumor size were independent predictors for OS of NSCLC patients. In conclusion, reduced miR-105-1 expression in NSCLC tissues is associated with poor OS and DFS of NSCLC patients.
format Online
Article
Text
id pubmed-5755234
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-57552342018-01-17 Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer Lu, Gaixia Fu, Da Jia, Chengyou Chai, Li Han, Yang Liu, Jin Wu, Tingmiao Xie, Ruting Chang, Zhengyan Yang, Huiqiong Luo, Pei Lv, Zhongwei Yu, Fei Zhong, Xiaojun Ma, Yushui Oncol Lett Articles Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and assessed miR-105-1 expression in 32 normal lung and 142 non-small cell lung cancer (NSCLC) tissue samples using reverse transcription-quantitative polymerase chain reaction. Survival data were calculated using Kaplan-Meier curves and a log-rank test. The stepwise forward Cox regression model was performed for univariate and multivariate analyses of independent predictor of overall survival (OS) of patients. The data on in silico and tissue microarray analyses of miRNA expression revealed reduced miR-105-1 expression in different types of human cancer, particularly in NSCLC. The level of miR-105-1 expression was confirmed to be downregulated in NSCLC tissues compared with that in normal lung tissues. Reduced miR-105-1 expression was associated with larger tumor size as well as poor OS and disease-free survival (DFS) of patients. Multivariate survival analysis demonstrated that reduced miR-105-1 expression and tumor size were independent predictors for OS of NSCLC patients. In conclusion, reduced miR-105-1 expression in NSCLC tissues is associated with poor OS and DFS of NSCLC patients. D.A. Spandidos 2017-12 2017-10-19 /pmc/articles/PMC5755234/ /pubmed/29344230 http://dx.doi.org/10.3892/ol.2017.7228 Text en Copyright: © Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Lu, Gaixia
Fu, Da
Jia, Chengyou
Chai, Li
Han, Yang
Liu, Jin
Wu, Tingmiao
Xie, Ruting
Chang, Zhengyan
Yang, Huiqiong
Luo, Pei
Lv, Zhongwei
Yu, Fei
Zhong, Xiaojun
Ma, Yushui
Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
title Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
title_full Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
title_fullStr Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
title_full_unstemmed Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
title_short Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
title_sort reduced mir-105-1 levels are associated with poor survival of patients with non-small cell lung cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755234/
https://www.ncbi.nlm.nih.gov/pubmed/29344230
http://dx.doi.org/10.3892/ol.2017.7228
work_keys_str_mv AT lugaixia reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT fuda reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT jiachengyou reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT chaili reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT hanyang reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT liujin reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT wutingmiao reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT xieruting reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT changzhengyan reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT yanghuiqiong reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT luopei reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT lvzhongwei reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT yufei reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT zhongxiaojun reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer
AT mayushui reducedmir1051levelsareassociatedwithpoorsurvivalofpatientswithnonsmallcelllungcancer