Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we...

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Detalles Bibliográficos
Autores principales: Vadodaria, Krishna C., Amatya, Debha N., Marchetto, Maria C., Gage, Fred H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755287/
https://www.ncbi.nlm.nih.gov/pubmed/29301565
http://dx.doi.org/10.1186/s13073-017-0512-3
Descripción
Sumario:Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

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