Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we...

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Autores principales: Vadodaria, Krishna C., Amatya, Debha N., Marchetto, Maria C., Gage, Fred H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755287/
https://www.ncbi.nlm.nih.gov/pubmed/29301565
http://dx.doi.org/10.1186/s13073-017-0512-3
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author Vadodaria, Krishna C.
Amatya, Debha N.
Marchetto, Maria C.
Gage, Fred H.
author_facet Vadodaria, Krishna C.
Amatya, Debha N.
Marchetto, Maria C.
Gage, Fred H.
author_sort Vadodaria, Krishna C.
collection PubMed
description Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.
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spelling pubmed-57552872018-01-08 Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward Vadodaria, Krishna C. Amatya, Debha N. Marchetto, Maria C. Gage, Fred H. Genome Med Comment Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges. BioMed Central 2018-01-04 /pmc/articles/PMC5755287/ /pubmed/29301565 http://dx.doi.org/10.1186/s13073-017-0512-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Vadodaria, Krishna C.
Amatya, Debha N.
Marchetto, Maria C.
Gage, Fred H.
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
title Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
title_full Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
title_fullStr Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
title_full_unstemmed Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
title_short Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
title_sort modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755287/
https://www.ncbi.nlm.nih.gov/pubmed/29301565
http://dx.doi.org/10.1186/s13073-017-0512-3
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