PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells

BACKGROUND: Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B participates in the promotion and development of tumors mostly by blocking the let-7...

Descripción completa

Detalles Bibliográficos
Autores principales: Qu, Ting-ting, Chen, Fei, Wang, Jing, Zhang, Yan-jun, Cheng, Mo-bin, Sun, Wen-zheng, Shen, Yu-fei, Zhang, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755467/
https://www.ncbi.nlm.nih.gov/pubmed/29301498
http://dx.doi.org/10.1186/s12885-017-3959-0

Ejemplares similares

Ejemplares similares