Cargando…

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse populations can increase power to detect complex trait loci when the underlying causal variants are shared between ancestry groups. However, heterogeneity in allelic effects between GWAS at these loci can occur that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mägi, Reedik, Horikoshi, Momoko, Sofer, Tamar, Mahajan, Anubha, Kitajima, Hidetoshi, Franceschini, Nora, McCarthy, Mark I., Morris, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Association Studies Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755684/ https://www.ncbi.nlm.nih.gov/pubmed/28911207 http://dx.doi.org/10.1093/hmg/ddx280

Ejemplares similares

Trans-ethnic study design approaches for fine-mapping
por: Asimit, Jennifer L, et al.
Publicado: (2016)

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity
por: Mahajan, Anubha, et al.
Publicado: (2016)

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms
por: Horikoshi, Momoko, et al.
Publicado: (2016)

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
por: Pervjakova, Natalia, et al.
Publicado: (2022)

Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample
por: Petty, Lauren E, et al.
Publicado: (2019)

Local Ancestry Inference in Large Pedigrees
por: Wang, Heming, et al.
Publicado: (2020)

GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer
por: Koel, Mariann, et al.
Publicado: (2023)

Genome-wide association study of toxic metals and trace elements reveals novel associations
por: Ng, Esther, et al.
Publicado: (2015)

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry
por: Nettleton, Jennifer A., et al.
Publicado: (2015)

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans
por: Fatumo, Segun, et al.
Publicado: (2021)

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
por: Pulit, Sara L, et al.
Publicado: (2019)

Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis
por: Choquet, Hélène, et al.
Publicado: (2022)

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus
por: Cannon, Maren E., et al.
Publicado: (2017)

Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
por: Laisk, Triin, et al.
Publicado: (2018)

African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
por: Behar, Doron M., et al.
Publicado: (2010)

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals
por: Marnetto, Davide, et al.
Publicado: (2020)

Trans-Ancestry Mutation Landscape of Hepatoblastoma Genomes in Children
por: Liu, Jie, et al.
Publicado: (2021)

How to account for Inuit ancestry in lung function prediction
por: Laustsen, Birgitte H, et al.
Publicado: (2022)

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations
por: Yoneyama, Sachiko, et al.
Publicado: (2016)

Large-Scale Analyses Provide No Evidence for Gene-Gene Interactions Influencing Type 2 Diabetes Risk
por: Nag, Abhishek, et al.
Publicado: (2020)

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma
por: Farahi, Neda, et al.
Publicado: (2017)

Associations
Publicado: (1860)

Ancestry-driven metabolite variation provides insights into disease states in admixed populations
por: Reynolds, Kaylia M., et al.
Publicado: (2023)

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans
por: Hanscombe, Ken B, et al.
Publicado: (2018)

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant
por: Almeida, Rodrigo, et al.
Publicado: (2014)

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
por: Orr, Nick, et al.
Publicado: (2015)

AFA: Ancestry-specific allele frequency estimation in admixed populations: The Hispanic Community Health Study/Study of Latinos
por: Granot-Hershkovitz, Einat, et al.
Publicado: (2022)

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
por: Surendran, Praveen, et al.
Publicado: (2016)

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?
por: Beaumont, Robin N., et al.
Publicado: (2017)

Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s disease
por: Lake, Julie, et al.
Publicado: (2023)

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
por: Amin Al Olama, Ali, et al.
Publicado: (2015)

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk
por: Painter, Jodie N., et al.
Publicado: (2015)

A 15q11.2 microdeletion first identified in a pair of autistic monozygotic twins with regression
por: Zhang, Ying, et al.
Publicado: (2015)

Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans
por: Price, Alkes L., et al.
Publicado: (2008)

Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci(†)
por: Kirsten, Holger, et al.
Publicado: (2015)

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study
por: Gan, Wei, et al.
Publicado: (2017)

Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program
por: Khan, Alyna T., et al.
Publicado: (2022)

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression
por: Kote-Jarai, Zsofia, et al.
Publicado: (2013)

Causal relationships between obesity and the leading causes of death in women and men
por: Censin, Jenny C., et al.
Publicado: (2019)

Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine
por: Udler, Miriam S, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_nk6qelav124qvdscgvai5hiing