The central amygdala controls learning in the lateral amygdala

Experience-driven synaptic plasticity in the lateral amygdala (LA) is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala (CeA) participates in such learning process remains unclear. Here we show that PKC-δ-expressing CeA...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Kai, Ahrens, Sandra, Zhang, Xian, Schiff, Hillary, Ramakrishnan, Charu, Fenno, Lief, Deisseroth, Karl, Zhao, Fei, Luo, Min-Hua, Gong, Ling, He, Miao, Zhou, Pengcheng, Paninski, Liam, Li, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755715/
https://www.ncbi.nlm.nih.gov/pubmed/29184202
http://dx.doi.org/10.1038/s41593-017-0009-9
Descripción
Sumario:Experience-driven synaptic plasticity in the lateral amygdala (LA) is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala (CeA) participates in such learning process remains unclear. Here we show that PKC-δ-expressing CeA neurons are essential for the synaptic plasticity underlying learning in the LA, as they convey information about unconditioned stimulus to LA neurons during fear conditioning.

Ejemplares similares