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The central amygdala controls learning in the lateral amygdala
Experience-driven synaptic plasticity in the lateral amygdala (LA) is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala (CeA) participates in such learning process remains unclear. Here we show that PKC-δ-expressing CeA...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755715/ https://www.ncbi.nlm.nih.gov/pubmed/29184202 http://dx.doi.org/10.1038/s41593-017-0009-9 |
| _version_ | 1783290619073921024 |
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| author | Yu, Kai Ahrens, Sandra Zhang, Xian Schiff, Hillary Ramakrishnan, Charu Fenno, Lief Deisseroth, Karl Zhao, Fei Luo, Min-Hua Gong, Ling He, Miao Zhou, Pengcheng Paninski, Liam Li, Bo |
| author_facet | Yu, Kai Ahrens, Sandra Zhang, Xian Schiff, Hillary Ramakrishnan, Charu Fenno, Lief Deisseroth, Karl Zhao, Fei Luo, Min-Hua Gong, Ling He, Miao Zhou, Pengcheng Paninski, Liam Li, Bo |
| author_sort | Yu, Kai |
| collection | PubMed |
| description | Experience-driven synaptic plasticity in the lateral amygdala (LA) is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala (CeA) participates in such learning process remains unclear. Here we show that PKC-δ-expressing CeA neurons are essential for the synaptic plasticity underlying learning in the LA, as they convey information about unconditioned stimulus to LA neurons during fear conditioning. |
| format | Online Article Text |
| id | pubmed-5755715 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57557152018-04-23 The central amygdala controls learning in the lateral amygdala Yu, Kai Ahrens, Sandra Zhang, Xian Schiff, Hillary Ramakrishnan, Charu Fenno, Lief Deisseroth, Karl Zhao, Fei Luo, Min-Hua Gong, Ling He, Miao Zhou, Pengcheng Paninski, Liam Li, Bo Nat Neurosci Article Experience-driven synaptic plasticity in the lateral amygdala (LA) is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala (CeA) participates in such learning process remains unclear. Here we show that PKC-δ-expressing CeA neurons are essential for the synaptic plasticity underlying learning in the LA, as they convey information about unconditioned stimulus to LA neurons during fear conditioning. 2017-10-23 2017-12 /pmc/articles/PMC5755715/ /pubmed/29184202 http://dx.doi.org/10.1038/s41593-017-0009-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Yu, Kai Ahrens, Sandra Zhang, Xian Schiff, Hillary Ramakrishnan, Charu Fenno, Lief Deisseroth, Karl Zhao, Fei Luo, Min-Hua Gong, Ling He, Miao Zhou, Pengcheng Paninski, Liam Li, Bo The central amygdala controls learning in the lateral amygdala |
| title | The central amygdala controls learning in the lateral amygdala |
| title_full | The central amygdala controls learning in the lateral amygdala |
| title_fullStr | The central amygdala controls learning in the lateral amygdala |
| title_full_unstemmed | The central amygdala controls learning in the lateral amygdala |
| title_short | The central amygdala controls learning in the lateral amygdala |
| title_sort | central amygdala controls learning in the lateral amygdala |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755715/ https://www.ncbi.nlm.nih.gov/pubmed/29184202 http://dx.doi.org/10.1038/s41593-017-0009-9 |
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