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Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain

Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable L...

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Autores principales: Kerrigan, Deanna, Mantsios, Andrea, Gorgolas, Miguel, Montes, Maria-Luisa, Pulido, Federico, Brinson, Cynthia, deVente, Jerome, Richmond, Gary J., Beckham, Sarah W., Hammond, Paige, Margolis, David, Murray, Miranda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755771/
https://www.ncbi.nlm.nih.gov/pubmed/29304154
http://dx.doi.org/10.1371/journal.pone.0190487
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author Kerrigan, Deanna
Mantsios, Andrea
Gorgolas, Miguel
Montes, Maria-Luisa
Pulido, Federico
Brinson, Cynthia
deVente, Jerome
Richmond, Gary J.
Beckham, Sarah W.
Hammond, Paige
Margolis, David
Murray, Miranda
author_facet Kerrigan, Deanna
Mantsios, Andrea
Gorgolas, Miguel
Montes, Maria-Luisa
Pulido, Federico
Brinson, Cynthia
deVente, Jerome
Richmond, Gary J.
Beckham, Sarah W.
Hammond, Paige
Margolis, David
Murray, Miranda
author_sort Kerrigan, Deanna
collection PubMed
description Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable LA regimen in the U.S. and Spain. Interviews exploring participant and provider attitudes and experiences with LA versus oral ART were audiotaped, transcribed and analyzed using thematic content analysis. Participants described the convenience of LA injections versus daily pills and emotional benefits such as minimized potential for HIV disclosure and eliminating the “daily reminder of living with HIV.” Providers recognized benefits but cautioned that LA candidates still need to adhere to clinic visits for injections and raised questions around ongoing clinical management. LA was seen as preferable to daily oral ART among PLHIV. Further research is needed regarding appropriate candidates, including with women and “non-adherent” populations across settings.
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spelling pubmed-57557712018-01-26 Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain Kerrigan, Deanna Mantsios, Andrea Gorgolas, Miguel Montes, Maria-Luisa Pulido, Federico Brinson, Cynthia deVente, Jerome Richmond, Gary J. Beckham, Sarah W. Hammond, Paige Margolis, David Murray, Miranda PLoS One Research Article Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable LA regimen in the U.S. and Spain. Interviews exploring participant and provider attitudes and experiences with LA versus oral ART were audiotaped, transcribed and analyzed using thematic content analysis. Participants described the convenience of LA injections versus daily pills and emotional benefits such as minimized potential for HIV disclosure and eliminating the “daily reminder of living with HIV.” Providers recognized benefits but cautioned that LA candidates still need to adhere to clinic visits for injections and raised questions around ongoing clinical management. LA was seen as preferable to daily oral ART among PLHIV. Further research is needed regarding appropriate candidates, including with women and “non-adherent” populations across settings. Public Library of Science 2018-01-05 /pmc/articles/PMC5755771/ /pubmed/29304154 http://dx.doi.org/10.1371/journal.pone.0190487 Text en © 2018 Kerrigan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kerrigan, Deanna
Mantsios, Andrea
Gorgolas, Miguel
Montes, Maria-Luisa
Pulido, Federico
Brinson, Cynthia
deVente, Jerome
Richmond, Gary J.
Beckham, Sarah W.
Hammond, Paige
Margolis, David
Murray, Miranda
Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
title Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
title_full Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
title_fullStr Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
title_full_unstemmed Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
title_short Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
title_sort experiences with long acting injectable art: a qualitative study among plhiv participating in a phase ii study of cabotegravir + rilpivirine (latte-2) in the united states and spain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755771/
https://www.ncbi.nlm.nih.gov/pubmed/29304154
http://dx.doi.org/10.1371/journal.pone.0190487
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