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Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable L...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755771/ https://www.ncbi.nlm.nih.gov/pubmed/29304154 http://dx.doi.org/10.1371/journal.pone.0190487 |
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author | Kerrigan, Deanna Mantsios, Andrea Gorgolas, Miguel Montes, Maria-Luisa Pulido, Federico Brinson, Cynthia deVente, Jerome Richmond, Gary J. Beckham, Sarah W. Hammond, Paige Margolis, David Murray, Miranda |
author_facet | Kerrigan, Deanna Mantsios, Andrea Gorgolas, Miguel Montes, Maria-Luisa Pulido, Federico Brinson, Cynthia deVente, Jerome Richmond, Gary J. Beckham, Sarah W. Hammond, Paige Margolis, David Murray, Miranda |
author_sort | Kerrigan, Deanna |
collection | PubMed |
description | Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable LA regimen in the U.S. and Spain. Interviews exploring participant and provider attitudes and experiences with LA versus oral ART were audiotaped, transcribed and analyzed using thematic content analysis. Participants described the convenience of LA injections versus daily pills and emotional benefits such as minimized potential for HIV disclosure and eliminating the “daily reminder of living with HIV.” Providers recognized benefits but cautioned that LA candidates still need to adhere to clinic visits for injections and raised questions around ongoing clinical management. LA was seen as preferable to daily oral ART among PLHIV. Further research is needed regarding appropriate candidates, including with women and “non-adherent” populations across settings. |
format | Online Article Text |
id | pubmed-5755771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57557712018-01-26 Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain Kerrigan, Deanna Mantsios, Andrea Gorgolas, Miguel Montes, Maria-Luisa Pulido, Federico Brinson, Cynthia deVente, Jerome Richmond, Gary J. Beckham, Sarah W. Hammond, Paige Margolis, David Murray, Miranda PLoS One Research Article Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable LA regimen in the U.S. and Spain. Interviews exploring participant and provider attitudes and experiences with LA versus oral ART were audiotaped, transcribed and analyzed using thematic content analysis. Participants described the convenience of LA injections versus daily pills and emotional benefits such as minimized potential for HIV disclosure and eliminating the “daily reminder of living with HIV.” Providers recognized benefits but cautioned that LA candidates still need to adhere to clinic visits for injections and raised questions around ongoing clinical management. LA was seen as preferable to daily oral ART among PLHIV. Further research is needed regarding appropriate candidates, including with women and “non-adherent” populations across settings. Public Library of Science 2018-01-05 /pmc/articles/PMC5755771/ /pubmed/29304154 http://dx.doi.org/10.1371/journal.pone.0190487 Text en © 2018 Kerrigan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kerrigan, Deanna Mantsios, Andrea Gorgolas, Miguel Montes, Maria-Luisa Pulido, Federico Brinson, Cynthia deVente, Jerome Richmond, Gary J. Beckham, Sarah W. Hammond, Paige Margolis, David Murray, Miranda Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain |
title | Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain |
title_full | Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain |
title_fullStr | Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain |
title_full_unstemmed | Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain |
title_short | Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain |
title_sort | experiences with long acting injectable art: a qualitative study among plhiv participating in a phase ii study of cabotegravir + rilpivirine (latte-2) in the united states and spain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755771/ https://www.ncbi.nlm.nih.gov/pubmed/29304154 http://dx.doi.org/10.1371/journal.pone.0190487 |
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