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Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation

OBJECTIVE: Aortic valve disease is a complex process characterized by valve interstitial cell activation, disruption of the extracellular matrix culminating in valve mineralization occurring over many years. We explored the function of the retinoblastoma protein (pRb) in aortic valve disease, given...

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Detalles Bibliográficos
Autores principales:	Freytsis, Marina, Baugh, Lauren, Liu, Zhiyi, Georgakoudi, Irene, Hinds, Philip W., Black, Lauren D., Huggins, Gordon S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755794/ https://www.ncbi.nlm.nih.gov/pubmed/29304157 http://dx.doi.org/10.1371/journal.pone.0190623

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