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The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs?
BACKGROUND: Aurochs (Bos primigenius) were distributed throughout large parts of Eurasia and Northern Africa during the late Pleistocene and the early Holocene, and all modern cattle are derived from the aurochs. Although the mtDNA haplogroups of most modern cattle belong to haplogroups T and I, sev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755918/ https://www.ncbi.nlm.nih.gov/pubmed/29304129 http://dx.doi.org/10.1371/journal.pone.0190937 |
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author | Noda, Aoi Yonesaka, Riku Sasazaki, Shinji Mannen, Hideyuki |
author_facet | Noda, Aoi Yonesaka, Riku Sasazaki, Shinji Mannen, Hideyuki |
author_sort | Noda, Aoi |
collection | PubMed |
description | BACKGROUND: Aurochs (Bos primigenius) were distributed throughout large parts of Eurasia and Northern Africa during the late Pleistocene and the early Holocene, and all modern cattle are derived from the aurochs. Although the mtDNA haplogroups of most modern cattle belong to haplogroups T and I, several additional haplogroups (P, Q, R, C and E) have been identified in modern cattle and aurochs. Haplogroup P was the most common haplogroup in European aurochs, but so far, it has been identified in only three of >3,000 submitted haplotypes of modern Asian cattle. METHODOLOGY: We sequenced the complete mtDNA D-loop region of 181 Japanese Shorthorn cattle and analyzed these together with representative bovine mtDNA sequences. The haplotype P of Japanese Shorthorn cattle was analyzed along with that of 36 previously published European aurochs and three modern Asian cattle sequences using the hypervariable 410 bp of the D-loop region. CONCLUSIONS: We detected the mtDNA haplogroup P in Japanese Shorthorn cattle with an extremely high frequency (83/181). Phylogenetic networks revealed two main clusters, designated as Pa for haplogroup P in European aurochs and Pc in modern Asian cattle. We also report the genetic diversity of haplogroup P compared with the sequences of extinct aurochs. No shared haplotypes are observed between the European aurochs and the modern Asian cattle. This finding suggests the possibility of local and secondary introgression events of haplogroup P in northeast Asian cattle, and will contribute to a better understanding of its origin and genetic diversity. |
format | Online Article Text |
id | pubmed-5755918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57559182018-01-26 The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? Noda, Aoi Yonesaka, Riku Sasazaki, Shinji Mannen, Hideyuki PLoS One Research Article BACKGROUND: Aurochs (Bos primigenius) were distributed throughout large parts of Eurasia and Northern Africa during the late Pleistocene and the early Holocene, and all modern cattle are derived from the aurochs. Although the mtDNA haplogroups of most modern cattle belong to haplogroups T and I, several additional haplogroups (P, Q, R, C and E) have been identified in modern cattle and aurochs. Haplogroup P was the most common haplogroup in European aurochs, but so far, it has been identified in only three of >3,000 submitted haplotypes of modern Asian cattle. METHODOLOGY: We sequenced the complete mtDNA D-loop region of 181 Japanese Shorthorn cattle and analyzed these together with representative bovine mtDNA sequences. The haplotype P of Japanese Shorthorn cattle was analyzed along with that of 36 previously published European aurochs and three modern Asian cattle sequences using the hypervariable 410 bp of the D-loop region. CONCLUSIONS: We detected the mtDNA haplogroup P in Japanese Shorthorn cattle with an extremely high frequency (83/181). Phylogenetic networks revealed two main clusters, designated as Pa for haplogroup P in European aurochs and Pc in modern Asian cattle. We also report the genetic diversity of haplogroup P compared with the sequences of extinct aurochs. No shared haplotypes are observed between the European aurochs and the modern Asian cattle. This finding suggests the possibility of local and secondary introgression events of haplogroup P in northeast Asian cattle, and will contribute to a better understanding of its origin and genetic diversity. Public Library of Science 2018-01-05 /pmc/articles/PMC5755918/ /pubmed/29304129 http://dx.doi.org/10.1371/journal.pone.0190937 Text en © 2018 Noda et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Noda, Aoi Yonesaka, Riku Sasazaki, Shinji Mannen, Hideyuki The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? |
title | The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? |
title_full | The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? |
title_fullStr | The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? |
title_full_unstemmed | The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? |
title_short | The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs? |
title_sort | mtdna haplogroup p of modern asian cattle: a genetic legacy of asian aurochs? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755918/ https://www.ncbi.nlm.nih.gov/pubmed/29304129 http://dx.doi.org/10.1371/journal.pone.0190937 |
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