Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome

Klinefelter syndrome (KS) is associated with increased incidence of thrombotic events. Hypofibrinolysis is associated with increased risk of thromboembolism. Although testosterone replacement therapy (TRT) inhibits the hypofibrinolysis, it can still cause thrombosis paradoxically due to increased do...

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Autores principales: Amjad, Waseem, Khatoon, Salma, Tarasaria, Twara, Sharifova, Gulru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755944/
https://www.ncbi.nlm.nih.gov/pubmed/29321947
http://dx.doi.org/10.7759/cureus.1823
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author Amjad, Waseem
Khatoon, Salma
Tarasaria, Twara
Sharifova, Gulru
author_facet Amjad, Waseem
Khatoon, Salma
Tarasaria, Twara
Sharifova, Gulru
author_sort Amjad, Waseem
collection PubMed
description Klinefelter syndrome (KS) is associated with increased incidence of thrombotic events. Hypofibrinolysis is associated with increased risk of thromboembolism. Although testosterone replacement therapy (TRT) inhibits the hypofibrinolysis, it can still cause thrombosis paradoxically due to increased dose and duration of use. Herein, we present a case of a young male diagnosed with KS who was taking testosterone. The dose was increased to boost the energy levels, and the patient presented with abdominal pain. Computed tomography (CT) of the abdomen showed extensive portal vein thrombosis. He was started on enoxaparin followed by apixaban. Studies need to be done regarding the need for thromboembolism prophylaxis in patients on TRT.
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spelling pubmed-57559442018-01-10 Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome Amjad, Waseem Khatoon, Salma Tarasaria, Twara Sharifova, Gulru Cureus Internal Medicine Klinefelter syndrome (KS) is associated with increased incidence of thrombotic events. Hypofibrinolysis is associated with increased risk of thromboembolism. Although testosterone replacement therapy (TRT) inhibits the hypofibrinolysis, it can still cause thrombosis paradoxically due to increased dose and duration of use. Herein, we present a case of a young male diagnosed with KS who was taking testosterone. The dose was increased to boost the energy levels, and the patient presented with abdominal pain. Computed tomography (CT) of the abdomen showed extensive portal vein thrombosis. He was started on enoxaparin followed by apixaban. Studies need to be done regarding the need for thromboembolism prophylaxis in patients on TRT. Cureus 2017-11-06 /pmc/articles/PMC5755944/ /pubmed/29321947 http://dx.doi.org/10.7759/cureus.1823 Text en Copyright © 2017, Amjad et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Amjad, Waseem
Khatoon, Salma
Tarasaria, Twara
Sharifova, Gulru
Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome
title Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome
title_full Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome
title_fullStr Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome
title_full_unstemmed Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome
title_short Portal Vein Thrombosis Due to an Increase in Dose of Testosterone in a Young Man with Klinefelter Syndrome
title_sort portal vein thrombosis due to an increase in dose of testosterone in a young man with klinefelter syndrome
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755944/
https://www.ncbi.nlm.nih.gov/pubmed/29321947
http://dx.doi.org/10.7759/cureus.1823
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AT sharifovagulru portalveinthrombosisduetoanincreaseindoseoftestosteroneinayoungmanwithklinefeltersyndrome

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