A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo

Alternative splicing of the oncogene MDM2 is induced in response to genotoxic stress. MDM2-ALT1, the major splice variant generated, is known to activate the p53 pathway and impede full-length MDM2’s negative regulation of p53. Despite this perceptible tumor-suppressive role, MDM2-ALT1 is also assoc...

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Detalles Bibliográficos
Autores principales: Comiskey, Daniel F., Jacob, Aishwarya G., Sanford, Brianne L., Montes, Matías, Goodwin, Andrew K., Steiner, Haley, Matsa, Eleftheria, Tapia-Santos, Aixa S., Bebee, Thomas W., Grieves, Jessica, La Perle, Krista, Boyaka, Prosper, Chandler, Dawn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756115/
https://www.ncbi.nlm.nih.gov/pubmed/28892044
http://dx.doi.org/10.1038/onc.2017.282

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