Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term

Parkinson’s disease is characterized by degeneration of substantia nigra dopamine neurons and by intraneuronal aggregates, primarily composed of misfolded α-synuclein. The α-synuclein aggregates in Parkinson’s patients are suggested to first appear in the olfactory bulb and enteric nerves and then p...

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Detalles Bibliográficos
Autores principales: Rey, Nolwen L., George, Sonia, Steiner, Jennifer A., Madaj, Zachary, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y., Brundin, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756266/
https://www.ncbi.nlm.nih.gov/pubmed/29209768
http://dx.doi.org/10.1007/s00401-017-1792-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756266/
https://www.ncbi.nlm.nih.gov/pubmed/29209768
http://dx.doi.org/10.1007/s00401-017-1792-9

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