GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

BACKGROUND: Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from pathogenic influenza infection in mice, but the mechanisms of protection and tre...

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Detalles Bibliográficos
Autores principales: Halstead, E. Scott, Umstead, Todd M., Davies, Michael L., Kawasawa, Yuka Imamura, Silveyra, Patricia, Howyrlak, Judie, Yang, Linlin, Guo, Weichao, Hu, Sanmei, Hewage, Eranda Kurundu, Chroneos, Zissis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756339/
https://www.ncbi.nlm.nih.gov/pubmed/29304863
http://dx.doi.org/10.1186/s12931-017-0708-5

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