Cargando…

Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake

BACKGROUND: Laquinimod is an immunomodulatory drug under clinical investigation for the treatment of the progressive form of multiple sclerosis (MS) with both anti-inflammatory and neuroprotective effects. Excitotoxicity, a prominent pathophysiological feature of MS and of its animal model, experime...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gentile, Antonietta, Musella, Alessandra, De Vito, Francesca, Fresegna, Diego, Bullitta, Silvia, Rizzo, Francesca Romana, Centonze, Diego, Mandolesi, Georgia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756343/ https://www.ncbi.nlm.nih.gov/pubmed/29304807 http://dx.doi.org/10.1186/s12974-017-1048-6

Ejemplares similares

Exploring the role of microglia in mood disorders associated with experimental multiple sclerosis
por: Gentile, Antonietta, et al.
Publicado: (2015)

Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions
por: Musella, Alessandra, et al.
Publicado: (2018)

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation
por: Rizzo, Francesca Romana, et al.
Publicado: (2018)

Immunomodulatory Effects of Exercise in Experimental Multiple Sclerosis
por: Gentile, Antonietta, et al.
Publicado: (2019)

Re-Examining the Role of TNF in MS Pathogenesis and Therapy
por: Fresegna, Diego, et al.
Publicado: (2020)

Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis
por: Musella, Alessandra, et al.
Publicado: (2020)

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
por: Gentile, Antonietta, et al.
Publicado: (2016)

Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
por: Gentile, Antonietta, et al.
Publicado: (2016)

Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis
por: Dolcetti, Ettore, et al.
Publicado: (2020)

Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis
por: Bruno, Antonio, et al.
Publicado: (2020)

Corrigendum: Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis
por: Bruno, Antonio, et al.
Publicado: (2021)

A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum
por: Musella, A., et al.
Publicado: (2017)

The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis
por: Mandolesi, Georgia, et al.
Publicado: (2021)

MiR‐142‐3p regulates synaptopathy‐driven disease progression in multiple sclerosis
por: De Vito, Francesca, et al.
Publicado: (2021)

Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis
por: Stampanoni Bassi, Mario, et al.
Publicado: (2019)

Modeling Resilience to Damage in Multiple Sclerosis: Plasticity Meets Connectivity
por: Stampanoni Bassi, Mario, et al.
Publicado: (2019)

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2018)

NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake
por: Yin, Anqi, et al.
Publicado: (2019)

Macrophage Plasticity and Polarization Are Altered in the Experimental Model of Multiple Sclerosis
por: Leuti, Alessandro, et al.
Publicado: (2021)

Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS
por: Rothhammer, Veit, et al.
Publicado: (2021)

The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity
por: Provenzano, Francesca, et al.
Publicado: (2023)

Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells
por: Kawakami, Zenji, et al.
Publicado: (2019)

An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats
por: Lu, Cheng-Wei, et al.
Publicado: (2022)

Ciliary Neurotrophic Factor Protects Striatal Neurons against Excitotoxicity by Enhancing Glial Glutamate Uptake
por: Beurrier, Corinne, et al.
Publicado: (2010)

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity
por: Moidunny, Shamsudheen, et al.
Publicado: (2016)

Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases
por: Ishikawa, Makoto
Publicado: (2013)

Platelet-derived growth factor predicts prolonged relapse-free period in multiple sclerosis
por: Stampanoni Bassi, Mario, et al.
Publicado: (2018)

Laquinimod Inhibits Inflammation-Induced Angiogenesis in the Cornea
por: Li, Zuohong, et al.
Publicado: (2020)

Laquinimod Supports Remyelination in Non-Supportive Environments
por: Nyamoya, Stella, et al.
Publicado: (2019)

Glutamate Excitotoxicity Inflicts Paranodal Myelin Splitting and Retraction
por: Fu, Yan, et al.
Publicado: (2009)

Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis
por: Takeda, Atsushi
Publicado: (2010)

Dopamine protects neurons against glutamate-induced excitotoxicity
por: Vaarmann, A, et al.
Publicado: (2013)

Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
por: Krasil’nikova, Irina, et al.
Publicado: (2019)

Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
por: Zgodova, Arina, et al.
Publicado: (2022)

The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis
por: Dolcetti, Ettore, et al.
Publicado: (2022)

Interleukin 6 SNP rs1818879 Regulates Radiological and Inflammatory Activity in Multiple Sclerosis
por: Bruno, Antonio, et al.
Publicado: (2022)

Laquinimod Therapy in Multiple Sclerosis: A Comprehensive Review
por: Kolb-Sobieraj, Channa, et al.
Publicado: (2014)

A phase II study of laquinimod in Crohn's disease
por: D'Haens, Geert, et al.
Publicado: (2015)

Laquinimod treatment in the R6/2 mouse model
por: Ellrichmann, Gisa, et al.
Publicado: (2017)

Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis
por: Nisticò, Robert, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_31tbhaobqdmgt9uo33hnfc6m3q