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Attributable causes of colorectal cancer in China

BACKGROUND: Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of colorectal cancer incidence and mortality attributable to the known risk factors in...

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Autores principales: Gu, Meng-Jia, Huang, Qiu-Chi, Bao, Cheng-Zhen, Li, Ying-Jun, Li, Xiao-Qin, Ye, Ding, Ye, Zhen-Hua, Chen, Kun, Wang, Jian-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756355/
https://www.ncbi.nlm.nih.gov/pubmed/29304763
http://dx.doi.org/10.1186/s12885-017-3968-z
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author Gu, Meng-Jia
Huang, Qiu-Chi
Bao, Cheng-Zhen
Li, Ying-Jun
Li, Xiao-Qin
Ye, Ding
Ye, Zhen-Hua
Chen, Kun
Wang, Jian-Bing
author_facet Gu, Meng-Jia
Huang, Qiu-Chi
Bao, Cheng-Zhen
Li, Ying-Jun
Li, Xiao-Qin
Ye, Ding
Ye, Zhen-Hua
Chen, Kun
Wang, Jian-Bing
author_sort Gu, Meng-Jia
collection PubMed
description BACKGROUND: Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of colorectal cancer incidence and mortality attributable to the known risk factors in China. METHODS: We estimated the population attributable faction (PAF) for each selected risk factor in China, based on the prevalence of exposure around 2000 and relative risks from cohort studies and meta-analyses. RESULTS: Among 245,000 new cases and 139,000 deaths of colorectal cancer in China in 2012, we found that 115,578 incident cases and 63,102 deaths of colorectal cancer were attributable to smoking, alcohol drinking, overweight and obesity, physical inactivity and dietary factors. Low vegetable intake was the main risk factor for colorectal cancer with a PAF of 17.9%. Physical inactivity was responsible for 8.9% of colorectal cancer incidence and mortality. The remaining factors, including high red and processed meat intake, low fruit intake, alcohol drinking, overweight/obesity and smoking, accounted for 8.6%, 6.4%, 5.4%, 5.3% and 4.9% of colorectal cancer, respectively. Overall, 45.5% of colorectal cancer incidence and mortality were attributable to the joint effects of these seven risk factors. CONCLUSIONS: Tobacco smoking, alcohol drinking, overweight or obesity, physical inactivity, low vegetable intake, low fruit intake, and high red and processed meat intake were responsible for nearly 46% of colorectal cancer incidence and mortality in China in 2012. Our findings could provide a basis for developing guidelines of colorectal cancer prevention and control in China.
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spelling pubmed-57563552018-01-08 Attributable causes of colorectal cancer in China Gu, Meng-Jia Huang, Qiu-Chi Bao, Cheng-Zhen Li, Ying-Jun Li, Xiao-Qin Ye, Ding Ye, Zhen-Hua Chen, Kun Wang, Jian-Bing BMC Cancer Research Article BACKGROUND: Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of colorectal cancer incidence and mortality attributable to the known risk factors in China. METHODS: We estimated the population attributable faction (PAF) for each selected risk factor in China, based on the prevalence of exposure around 2000 and relative risks from cohort studies and meta-analyses. RESULTS: Among 245,000 new cases and 139,000 deaths of colorectal cancer in China in 2012, we found that 115,578 incident cases and 63,102 deaths of colorectal cancer were attributable to smoking, alcohol drinking, overweight and obesity, physical inactivity and dietary factors. Low vegetable intake was the main risk factor for colorectal cancer with a PAF of 17.9%. Physical inactivity was responsible for 8.9% of colorectal cancer incidence and mortality. The remaining factors, including high red and processed meat intake, low fruit intake, alcohol drinking, overweight/obesity and smoking, accounted for 8.6%, 6.4%, 5.4%, 5.3% and 4.9% of colorectal cancer, respectively. Overall, 45.5% of colorectal cancer incidence and mortality were attributable to the joint effects of these seven risk factors. CONCLUSIONS: Tobacco smoking, alcohol drinking, overweight or obesity, physical inactivity, low vegetable intake, low fruit intake, and high red and processed meat intake were responsible for nearly 46% of colorectal cancer incidence and mortality in China in 2012. Our findings could provide a basis for developing guidelines of colorectal cancer prevention and control in China. BioMed Central 2018-01-05 /pmc/articles/PMC5756355/ /pubmed/29304763 http://dx.doi.org/10.1186/s12885-017-3968-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gu, Meng-Jia
Huang, Qiu-Chi
Bao, Cheng-Zhen
Li, Ying-Jun
Li, Xiao-Qin
Ye, Ding
Ye, Zhen-Hua
Chen, Kun
Wang, Jian-Bing
Attributable causes of colorectal cancer in China
title Attributable causes of colorectal cancer in China
title_full Attributable causes of colorectal cancer in China
title_fullStr Attributable causes of colorectal cancer in China
title_full_unstemmed Attributable causes of colorectal cancer in China
title_short Attributable causes of colorectal cancer in China
title_sort attributable causes of colorectal cancer in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756355/
https://www.ncbi.nlm.nih.gov/pubmed/29304763
http://dx.doi.org/10.1186/s12885-017-3968-z
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