Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer

BACKGROUND: NRF2 is the key regulator of oxidative stress in normal cells and aberrant expression of the NRF2 pathway due to genetic alterations in the KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid 2 like 2)-CUL3 (cullin 3) axis leads to tumorigenesis and drug resistance...

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Detalles Bibliográficos
Autores principales: Namani, Akhileshwar, Matiur Rahaman, Md., Chen, Ming, Tang, Xiuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756380/
https://www.ncbi.nlm.nih.gov/pubmed/29306329
http://dx.doi.org/10.1186/s12885-017-3907-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756380/
https://www.ncbi.nlm.nih.gov/pubmed/29306329
http://dx.doi.org/10.1186/s12885-017-3907-z

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