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Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

BACKGROUND: Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileum may facilitate removal of free cholesterol from the live...

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Detalles Bibliográficos
Autores principales:	Tiessen, Renger G., Kennedy, Ciara A., Keller, Bradley T., Levin, Nancy, Acevedo, Lisette, Gedulin, Bronislava, van Vliet, Andre A., Dorenbaum, Alejandro, Palmer, Melissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756385/ https://www.ncbi.nlm.nih.gov/pubmed/29304731 http://dx.doi.org/10.1186/s12876-017-0736-0

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