Cargando…
Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications
Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progression require further exploration. Based on accumulating evidence, extracellular vesicles, incl...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756395/ https://www.ncbi.nlm.nih.gov/pubmed/29304816 http://dx.doi.org/10.1186/s12943-017-0755-z |
_version_ | 1783290721338392576 |
---|---|
author | Qiu, Jiangdong Yang, Gang Feng, Mengyu Zheng, Suli Cao, Zhe You, Lei Zheng, Lianfang Zhang, Taiping Zhao, Yupei |
author_facet | Qiu, Jiangdong Yang, Gang Feng, Mengyu Zheng, Suli Cao, Zhe You, Lei Zheng, Lianfang Zhang, Taiping Zhao, Yupei |
author_sort | Qiu, Jiangdong |
collection | PubMed |
description | Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progression require further exploration. Based on accumulating evidence, extracellular vesicles, including exosomes and microvesicles, play a crucial role in pancreatic cancer progression and chemoresistance. Furthermore, they also possess the potential to be promising biomarkers, therapy targets and tools for treating pancreatic cancer. Therefore, in-depth studies on the role of extracellular vesicles in pancreatic cancer are meaningful. In this review, we focus on the regulatory effects of extracellular vesicles on pancreatic cancer progression, metastasis, cancer-related immunity and chemoresistance, particularly their potential roles as biomarkers and therapeutic targets. |
format | Online Article Text |
id | pubmed-5756395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57563952018-01-09 Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications Qiu, Jiangdong Yang, Gang Feng, Mengyu Zheng, Suli Cao, Zhe You, Lei Zheng, Lianfang Zhang, Taiping Zhao, Yupei Mol Cancer Review Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms, early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to pancreatic cancer progression require further exploration. Based on accumulating evidence, extracellular vesicles, including exosomes and microvesicles, play a crucial role in pancreatic cancer progression and chemoresistance. Furthermore, they also possess the potential to be promising biomarkers, therapy targets and tools for treating pancreatic cancer. Therefore, in-depth studies on the role of extracellular vesicles in pancreatic cancer are meaningful. In this review, we focus on the regulatory effects of extracellular vesicles on pancreatic cancer progression, metastasis, cancer-related immunity and chemoresistance, particularly their potential roles as biomarkers and therapeutic targets. BioMed Central 2018-01-05 /pmc/articles/PMC5756395/ /pubmed/29304816 http://dx.doi.org/10.1186/s12943-017-0755-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Qiu, Jiangdong Yang, Gang Feng, Mengyu Zheng, Suli Cao, Zhe You, Lei Zheng, Lianfang Zhang, Taiping Zhao, Yupei Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
title | Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
title_full | Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
title_fullStr | Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
title_full_unstemmed | Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
title_short | Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
title_sort | extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756395/ https://www.ncbi.nlm.nih.gov/pubmed/29304816 http://dx.doi.org/10.1186/s12943-017-0755-z |
work_keys_str_mv | AT qiujiangdong extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT yanggang extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT fengmengyu extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT zhengsuli extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT caozhe extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT youlei extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT zhenglianfang extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT zhangtaiping extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications AT zhaoyupei extracellularvesiclesasmediatorsoftheprogressionandchemoresistanceofpancreaticcancerandtheirpotentialclinicalapplications |