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A historical legacy of antibiotic utilization on bacterial seed banks in sediments
The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756452/ https://www.ncbi.nlm.nih.gov/pubmed/29312823 http://dx.doi.org/10.7717/peerj.4197 |
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author | Madueño, Laura Paul, Christophe Junier, Thomas Bayrychenko, Zhanna Filippidou, Sevasti Beck, Karin Greub, Gilbert Bürgmann, Helmut Junier, Pilar |
author_facet | Madueño, Laura Paul, Christophe Junier, Thomas Bayrychenko, Zhanna Filippidou, Sevasti Beck, Karin Greub, Gilbert Bürgmann, Helmut Junier, Pilar |
author_sort | Madueño, Laura |
collection | PubMed |
description | The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence. |
format | Online Article Text |
id | pubmed-5756452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57564522018-01-08 A historical legacy of antibiotic utilization on bacterial seed banks in sediments Madueño, Laura Paul, Christophe Junier, Thomas Bayrychenko, Zhanna Filippidou, Sevasti Beck, Karin Greub, Gilbert Bürgmann, Helmut Junier, Pilar PeerJ Ecology The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence. PeerJ Inc. 2018-01-03 /pmc/articles/PMC5756452/ /pubmed/29312823 http://dx.doi.org/10.7717/peerj.4197 Text en ©2018 Madueño et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Ecology Madueño, Laura Paul, Christophe Junier, Thomas Bayrychenko, Zhanna Filippidou, Sevasti Beck, Karin Greub, Gilbert Bürgmann, Helmut Junier, Pilar A historical legacy of antibiotic utilization on bacterial seed banks in sediments |
title | A historical legacy of antibiotic utilization on bacterial seed banks in sediments |
title_full | A historical legacy of antibiotic utilization on bacterial seed banks in sediments |
title_fullStr | A historical legacy of antibiotic utilization on bacterial seed banks in sediments |
title_full_unstemmed | A historical legacy of antibiotic utilization on bacterial seed banks in sediments |
title_short | A historical legacy of antibiotic utilization on bacterial seed banks in sediments |
title_sort | historical legacy of antibiotic utilization on bacterial seed banks in sediments |
topic | Ecology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756452/ https://www.ncbi.nlm.nih.gov/pubmed/29312823 http://dx.doi.org/10.7717/peerj.4197 |
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