Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner

BACKGROUND: The release of high mobility group box 1 (HMGB1) induced by inflammatory signals acts as a cellular alarmin to trigger a chain of inflammatory responses. Although the inflammatory actions of HMGB1 are well studied, less is known about the therapeutic agents that can impede its release. T...

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Detalles Bibliográficos
Autores principales: Hwang, Jung Seok, Kang, Eun Sil, Han, Sung Gu, Lim, Dae-Seog, Paek, Kyung Shin, Lee, Chi-Ho, Seo, Han Geuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756453/
https://www.ncbi.nlm.nih.gov/pubmed/29312829
http://dx.doi.org/10.7717/peerj.4208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756453/
https://www.ncbi.nlm.nih.gov/pubmed/29312829
http://dx.doi.org/10.7717/peerj.4208

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