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Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma

BACKGROUND: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. AIM: Our study aimed to analyze PN expression in different histolo...

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Autores principales: Giusca, Simona Eliza, Amalinei, Cornelia, Lozneanu, Ludmila, Ciobanu Apostol, Delia, Andriescu, Elena Corina, Scripcariu, Alex, Balan, Raluca, Avadanei, Elena Roxana, Căruntu, Irina-Draga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757104/
https://www.ncbi.nlm.nih.gov/pubmed/29435461
http://dx.doi.org/10.1155/2017/8701386
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author Giusca, Simona Eliza
Amalinei, Cornelia
Lozneanu, Ludmila
Ciobanu Apostol, Delia
Andriescu, Elena Corina
Scripcariu, Alex
Balan, Raluca
Avadanei, Elena Roxana
Căruntu, Irina-Draga
author_facet Giusca, Simona Eliza
Amalinei, Cornelia
Lozneanu, Ludmila
Ciobanu Apostol, Delia
Andriescu, Elena Corina
Scripcariu, Alex
Balan, Raluca
Avadanei, Elena Roxana
Căruntu, Irina-Draga
author_sort Giusca, Simona Eliza
collection PubMed
description BACKGROUND: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. AIM: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors. MATERIAL AND METHODS: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated. RESULTS: Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type. CONCLUSIONS: Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable.
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spelling pubmed-57571042018-02-12 Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma Giusca, Simona Eliza Amalinei, Cornelia Lozneanu, Ludmila Ciobanu Apostol, Delia Andriescu, Elena Corina Scripcariu, Alex Balan, Raluca Avadanei, Elena Roxana Căruntu, Irina-Draga Biomed Res Int Research Article BACKGROUND: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. AIM: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors. MATERIAL AND METHODS: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated. RESULTS: Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type. CONCLUSIONS: Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable. Hindawi 2017 2017-12-25 /pmc/articles/PMC5757104/ /pubmed/29435461 http://dx.doi.org/10.1155/2017/8701386 Text en Copyright © 2017 Simona Eliza Giusca et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Giusca, Simona Eliza
Amalinei, Cornelia
Lozneanu, Ludmila
Ciobanu Apostol, Delia
Andriescu, Elena Corina
Scripcariu, Alex
Balan, Raluca
Avadanei, Elena Roxana
Căruntu, Irina-Draga
Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
title Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
title_full Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
title_fullStr Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
title_full_unstemmed Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
title_short Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
title_sort heterogeneous periostin expression in different histological variants of papillary thyroid carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757104/
https://www.ncbi.nlm.nih.gov/pubmed/29435461
http://dx.doi.org/10.1155/2017/8701386
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