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Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
BACKGROUND: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. AIM: Our study aimed to analyze PN expression in different histolo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757104/ https://www.ncbi.nlm.nih.gov/pubmed/29435461 http://dx.doi.org/10.1155/2017/8701386 |
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author | Giusca, Simona Eliza Amalinei, Cornelia Lozneanu, Ludmila Ciobanu Apostol, Delia Andriescu, Elena Corina Scripcariu, Alex Balan, Raluca Avadanei, Elena Roxana Căruntu, Irina-Draga |
author_facet | Giusca, Simona Eliza Amalinei, Cornelia Lozneanu, Ludmila Ciobanu Apostol, Delia Andriescu, Elena Corina Scripcariu, Alex Balan, Raluca Avadanei, Elena Roxana Căruntu, Irina-Draga |
author_sort | Giusca, Simona Eliza |
collection | PubMed |
description | BACKGROUND: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. AIM: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors. MATERIAL AND METHODS: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated. RESULTS: Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type. CONCLUSIONS: Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable. |
format | Online Article Text |
id | pubmed-5757104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57571042018-02-12 Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma Giusca, Simona Eliza Amalinei, Cornelia Lozneanu, Ludmila Ciobanu Apostol, Delia Andriescu, Elena Corina Scripcariu, Alex Balan, Raluca Avadanei, Elena Roxana Căruntu, Irina-Draga Biomed Res Int Research Article BACKGROUND: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. AIM: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors. MATERIAL AND METHODS: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated. RESULTS: Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type. CONCLUSIONS: Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable. Hindawi 2017 2017-12-25 /pmc/articles/PMC5757104/ /pubmed/29435461 http://dx.doi.org/10.1155/2017/8701386 Text en Copyright © 2017 Simona Eliza Giusca et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Giusca, Simona Eliza Amalinei, Cornelia Lozneanu, Ludmila Ciobanu Apostol, Delia Andriescu, Elena Corina Scripcariu, Alex Balan, Raluca Avadanei, Elena Roxana Căruntu, Irina-Draga Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma |
title | Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma |
title_full | Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma |
title_fullStr | Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma |
title_full_unstemmed | Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma |
title_short | Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma |
title_sort | heterogeneous periostin expression in different histological variants of papillary thyroid carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757104/ https://www.ncbi.nlm.nih.gov/pubmed/29435461 http://dx.doi.org/10.1155/2017/8701386 |
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