A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway

Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1‐phosphate, a prosurvival lipid associated with proliferation, angiogenesis, and invasion. SK1 overexpression has been observed in numerous cancers. Recent studies have demonstrated that SK1 proteolysis occurs downstre...

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Detalles Bibliográficos
Autores principales: Carroll, Brittany L., Bonica, Joseph, Shamseddine, Achraf A., Hannun, Yusuf A., Obeid, Lina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757171/
https://www.ncbi.nlm.nih.gov/pubmed/29321954
http://dx.doi.org/10.1002/2211-5463.12344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757171/
https://www.ncbi.nlm.nih.gov/pubmed/29321954
http://dx.doi.org/10.1002/2211-5463.12344

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