Mutual influence of secondary and key drug‐resistance mutations on catalytic properties and thermal stability of TEM‐type β‐lactamases

Highly mutable β‐lactamases are responsible for the ability of Gram‐negative bacteria to resist β‐lactam antibiotics. Using site‐directed mutagenesis technique, we have produced in vitro a number of recombinant analogs of naturally occurring TEM‐type β‐lactamases, bearing the secondary substitution...

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Detalles Bibliográficos
Autores principales: Grigorenko, Vitaly, Uporov, Igor, Rubtsova, Maya, Andreeva, Irina, Shcherbinin, Dmitrii, Veselovsky, Alexander, Serova, Oksana, Ulyashova, Maria, Ishtubaev, Igor, Egorov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757180/
https://www.ncbi.nlm.nih.gov/pubmed/29321962
http://dx.doi.org/10.1002/2211-5463.12352

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