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Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis
PURPOSE: To report the case of a patient who presented with a vasculitic central retinal vein occlusion (CRVO), which was the result of an undiagnosed systemic inflammatory condition, seronegative rheumatoid arthritis (RA). OBSERVATIONS: The patient presented with reduced vision in the left eye and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757365/ https://www.ncbi.nlm.nih.gov/pubmed/29503893 http://dx.doi.org/10.1016/j.ajoc.2016.04.007 |
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author | Trese, Matthew G.J. Yonekawa, Yoshihiro Thomas, Benjamin J. Randhawa, Sandeep |
author_facet | Trese, Matthew G.J. Yonekawa, Yoshihiro Thomas, Benjamin J. Randhawa, Sandeep |
author_sort | Trese, Matthew G.J. |
collection | PubMed |
description | PURPOSE: To report the case of a patient who presented with a vasculitic central retinal vein occlusion (CRVO), which was the result of an undiagnosed systemic inflammatory condition, seronegative rheumatoid arthritis (RA). OBSERVATIONS: The patient presented with reduced vision in the left eye and polyarthralgia. Fundoscopic examination revealed a central retinal vein occlusion (CRVO) with concurrent evidence of vasculitis. Work-up for polyarthralgia included comprehensive serologic testing for connective tissue disease, including Vectra(®) disease activity (DA) testing. Results of these studies confirmed the diagnosis of seronegative rheumatoid arthritis (RA). Systemic steroid therapy was initiated with subsequent anatomic and visual improvement. CONCLUSIONS AND IMPORTANCE: We hypothesize that the systemic inflammation—a hallmark of RA—led to the development of a vasculitic CRVO and, thus, the retinal manifestations served as the disease marker that prompted thorough work-up of the patient's disease, even in the face of initial seronegativity. This case serves as a reminder that, in the setting of CRVO and polyarthralgia, systemic inflammatory conditions must be considered as the underlying etiology. Further, this case report highlights our evolving understanding of the role that serologic markers play in the diagnosis and monitoring of RA. |
format | Online Article Text |
id | pubmed-5757365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-57573652018-03-02 Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis Trese, Matthew G.J. Yonekawa, Yoshihiro Thomas, Benjamin J. Randhawa, Sandeep Am J Ophthalmol Case Rep Article PURPOSE: To report the case of a patient who presented with a vasculitic central retinal vein occlusion (CRVO), which was the result of an undiagnosed systemic inflammatory condition, seronegative rheumatoid arthritis (RA). OBSERVATIONS: The patient presented with reduced vision in the left eye and polyarthralgia. Fundoscopic examination revealed a central retinal vein occlusion (CRVO) with concurrent evidence of vasculitis. Work-up for polyarthralgia included comprehensive serologic testing for connective tissue disease, including Vectra(®) disease activity (DA) testing. Results of these studies confirmed the diagnosis of seronegative rheumatoid arthritis (RA). Systemic steroid therapy was initiated with subsequent anatomic and visual improvement. CONCLUSIONS AND IMPORTANCE: We hypothesize that the systemic inflammation—a hallmark of RA—led to the development of a vasculitic CRVO and, thus, the retinal manifestations served as the disease marker that prompted thorough work-up of the patient's disease, even in the face of initial seronegativity. This case serves as a reminder that, in the setting of CRVO and polyarthralgia, systemic inflammatory conditions must be considered as the underlying etiology. Further, this case report highlights our evolving understanding of the role that serologic markers play in the diagnosis and monitoring of RA. Elsevier 2016-04-18 /pmc/articles/PMC5757365/ /pubmed/29503893 http://dx.doi.org/10.1016/j.ajoc.2016.04.007 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Trese, Matthew G.J. Yonekawa, Yoshihiro Thomas, Benjamin J. Randhawa, Sandeep Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis |
title | Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis |
title_full | Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis |
title_fullStr | Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis |
title_full_unstemmed | Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis |
title_short | Vasculitic central retinal vein occlusion: The presenting sign of seronegative rheumatoid arthritis |
title_sort | vasculitic central retinal vein occlusion: the presenting sign of seronegative rheumatoid arthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757365/ https://www.ncbi.nlm.nih.gov/pubmed/29503893 http://dx.doi.org/10.1016/j.ajoc.2016.04.007 |
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