Cargando…

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Evers, Bret M., Rodriguez-Navas, Carlos, Tesla, Rachel J., Prange-Kiel, Janine, Wasser, Catherine R., Yoo, Kyoung Shin, McDonald, Jeffrey, Cenik, Basar, Ravenscroft, Thomas A., Plattner, Florian, Rademakers, Rosa, Yu, Gang, White, Charles L., Herz, Joachim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757843/ https://www.ncbi.nlm.nih.gov/pubmed/28903038 http://dx.doi.org/10.1016/j.celrep.2017.08.056

Ejemplares similares

Lysosomal processing of progranulin
por: Zhou, Xiaolai, et al.
Publicado: (2017)

Progranulin takes an alternate route to lysosomes
por: Short, Ben
Publicado: (2015)

Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin
por: Du, Huan, et al.
Publicado: (2022)

Prosaposin is a regulator of progranulin levels and oligomerization
por: Nicholson, Alexandra M., et al.
Publicado: (2016)

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
por: Zhou, Xiaolai, et al.
Publicado: (2015)

The lysosomal protein cathepsin L is a progranulin protease
por: Lee, Chris W., et al.
Publicado: (2017)

Delivering progranulin to neuronal lysosomes protects against excitotoxicity
por: Davis, Skylar E., et al.
Publicado: (2021)

Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes
por: Jian, Jinlong, et al.
Publicado: (2017)

Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
por: Dong, Tingting, et al.
Publicado: (2021)

Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
por: Gillett, Drew A., et al.
Publicado: (2023)

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
por: Lee, Wing C., et al.
Publicado: (2014)

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
por: Zhou, Xiaolai, et al.
Publicado: (2017)

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons
por: Hasan, Saadia, et al.
Publicado: (2023)

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
por: Hasan, Saadia, et al.
Publicado: (2023)

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
por: Reifschneider, Anika, et al.
Publicado: (2022)

Progranulin axis and recent developments in frontotemporal lobar degeneration
por: Nicholson, Alexandra M, et al.
Publicado: (2012)

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
por: Götzl, Julia K., et al.
Publicado: (2018)

Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
por: Tanaka, Yoshinori, et al.
Publicado: (2014)

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration
por: Mohan, Swetha, et al.
Publicado: (2021)

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency
por: Root, Jessica, et al.
Publicado: (2023)

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
por: Finch, NiCole, et al.
Publicado: (2009)

Progranulin regulates neuronal outgrowth independent of Sortilin
por: Gass, Jennifer, et al.
Publicado: (2012)

Commentary: Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
por: Sargeant, Timothy J.
Publicado: (2016)

Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
por: Werner, Georg, et al.
Publicado: (2020)

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein
por: Anderson, Abigail, et al.
Publicado: (2023)

Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43
por: Tanaka, Yoshinori, et al.
Publicado: (2023)

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for ‘The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C’ on page 236
por: Van Damme, Philip
Publicado: (2017)

Plasma sterols and depressive symptom severity in a population-based cohort
por: Cenik, Basar, et al.
Publicado: (2017)

Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency
por: Zhou, Xiaolai, et al.
Publicado: (2017)

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations
por: Holler, Christopher J., et al.
Publicado: (2017)

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
por: Frew, Jonathan, et al.
Publicado: (2020)

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology
por: Mendsaikhan, Anarmaa, et al.
Publicado: (2019)

Progranulin deficiency in Iba-1(+) myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation
por: Takahashi, Kei, et al.
Publicado: (2021)

Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis
por: Santos, Mariela Nunez, et al.
Publicado: (2022)

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
por: Sephton, Chantelle F., et al.
Publicado: (2011)

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
por: Arrant, Andrew E., et al.
Publicado: (2018)

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone
por: Cenik, Basar, et al.
Publicado: (2022)

Splicing therapeutics for Alzheimer's disease
por: Wasser, Catherine R, et al.
Publicado: (2016)

C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking
por: Zheng, Yanqiu, et al.
Publicado: (2011)

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice1,2,3
por: Arrant, Andrew E., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d968pggmdtimh8o6en2c9i4kjh