Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no medical therapies exist. CCMs arise from loss of an adaptor complex that negatively regulates MEKK3-KLF2/4 signaling in brain endothelial cells, but upstream activators of this disease pathway remain unknown. Here...

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Detalles Bibliográficos
Autores principales: Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757866/
https://www.ncbi.nlm.nih.gov/pubmed/28489816
http://dx.doi.org/10.1038/nature22075

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