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The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis

OBJECTIVE: This meta-analysis aimed to illustrate the efficacy and safety of preganalin for pain management in patients with postherpetic neuralgia (PHN). METHODS: In July 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Review...

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Autores principales: Wang, Suo-liang, Wang, Huan, Nie, Hui-yong, Bu, Gang, Shen, Xiao-dong, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758153/
https://www.ncbi.nlm.nih.gov/pubmed/29390451
http://dx.doi.org/10.1097/MD.0000000000009167
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author Wang, Suo-liang
Wang, Huan
Nie, Hui-yong
Bu, Gang
Shen, Xiao-dong
Wang, Hui
author_facet Wang, Suo-liang
Wang, Huan
Nie, Hui-yong
Bu, Gang
Shen, Xiao-dong
Wang, Hui
author_sort Wang, Suo-liang
collection PubMed
description OBJECTIVE: This meta-analysis aimed to illustrate the efficacy and safety of preganalin for pain management in patients with postherpetic neuralgia (PHN). METHODS: In July 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google database. Data on patients with PHN that compared pregabalin versus placebo were retrieved. The endpoints were the visual analog scale (VAS) at 8 weeks, the percentage of 30% and 50% pain responders; sleep interference score and improvement in patient global impression of change (PGIC). After testing for publication bias and heterogeneity between studies, data were aggregated for random-effects models when necessary. RESULTS: Seven clinical studies with 2192 patients (pregabalin group = 1381, control group = 811) were finally included in the meta-analysis. Pregabalin was associated with reduced pain scores at 8 weeks, corresponding to a reduction of 11.23 points (95% CI, −14.33, −8.13, P = .000) on a 100-point VAS. Pregabalin was also associated with a more percentage of 30% and 50% pain responders than controls (P < .05). Meanwhile, pregabalin can decrease sleep interference score and improvement in PGIC than control groups (P < .05). CONCLUSIONS: Pregabalin was efficacious in the reduction of postoperative pain and improvement the sleep quality in patients with PHN.
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spelling pubmed-57581532018-01-29 The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis Wang, Suo-liang Wang, Huan Nie, Hui-yong Bu, Gang Shen, Xiao-dong Wang, Hui Medicine (Baltimore) 7000 OBJECTIVE: This meta-analysis aimed to illustrate the efficacy and safety of preganalin for pain management in patients with postherpetic neuralgia (PHN). METHODS: In July 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google database. Data on patients with PHN that compared pregabalin versus placebo were retrieved. The endpoints were the visual analog scale (VAS) at 8 weeks, the percentage of 30% and 50% pain responders; sleep interference score and improvement in patient global impression of change (PGIC). After testing for publication bias and heterogeneity between studies, data were aggregated for random-effects models when necessary. RESULTS: Seven clinical studies with 2192 patients (pregabalin group = 1381, control group = 811) were finally included in the meta-analysis. Pregabalin was associated with reduced pain scores at 8 weeks, corresponding to a reduction of 11.23 points (95% CI, −14.33, −8.13, P = .000) on a 100-point VAS. Pregabalin was also associated with a more percentage of 30% and 50% pain responders than controls (P < .05). Meanwhile, pregabalin can decrease sleep interference score and improvement in PGIC than control groups (P < .05). CONCLUSIONS: Pregabalin was efficacious in the reduction of postoperative pain and improvement the sleep quality in patients with PHN. Wolters Kluwer Health 2017-12-22 /pmc/articles/PMC5758153/ /pubmed/29390451 http://dx.doi.org/10.1097/MD.0000000000009167 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 7000
Wang, Suo-liang
Wang, Huan
Nie, Hui-yong
Bu, Gang
Shen, Xiao-dong
Wang, Hui
The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis
title The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis
title_full The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis
title_fullStr The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis
title_full_unstemmed The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis
title_short The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis
title_sort efficacy of pregabalin for acute pain control in herpetic neuralgia patients: a meta-analysis
topic 7000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758153/
https://www.ncbi.nlm.nih.gov/pubmed/29390451
http://dx.doi.org/10.1097/MD.0000000000009167
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