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Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report

RATIONALE: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), whic...

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Autores principales: Mizuno, Shinta, Wakui, Masatoshi, Machida, Yujiro, Hosoe, Naoki, Hisamatsu, Tadakazu, Ishida, Takashi, Kameyama, Kaori, Naganuma, Makoto, Kanai, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758180/
https://www.ncbi.nlm.nih.gov/pubmed/29390478
http://dx.doi.org/10.1097/MD.0000000000009237
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author Mizuno, Shinta
Wakui, Masatoshi
Machida, Yujiro
Hosoe, Naoki
Hisamatsu, Tadakazu
Ishida, Takashi
Kameyama, Kaori
Naganuma, Makoto
Kanai, Takanori
author_facet Mizuno, Shinta
Wakui, Masatoshi
Machida, Yujiro
Hosoe, Naoki
Hisamatsu, Tadakazu
Ishida, Takashi
Kameyama, Kaori
Naganuma, Makoto
Kanai, Takanori
author_sort Mizuno, Shinta
collection PubMed
description RATIONALE: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. PATIENT CONCERN: In this report we described 2 active mesenteric panniculitis patients with high PGE-MUM levels. DIAGNOSES: Mesenteric panniculitis INTERVENTIONS: Both MP patients were measured the levels of PGE-MUM. OUTCOMES: Both MP patients exhibited high levels of PGE-MUM before treatment. In one, the levels were sensitively correlated with clinical symptoms and serological markers on steroids. LESSONS: The study observations suggest the potential of PGE-MUM to reflect the disease activity of MP. To verify its use, more findings based on clinical studies should be accumulated.
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spelling pubmed-57581802018-01-29 Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report Mizuno, Shinta Wakui, Masatoshi Machida, Yujiro Hosoe, Naoki Hisamatsu, Tadakazu Ishida, Takashi Kameyama, Kaori Naganuma, Makoto Kanai, Takanori Medicine (Baltimore) 4500 RATIONALE: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. PATIENT CONCERN: In this report we described 2 active mesenteric panniculitis patients with high PGE-MUM levels. DIAGNOSES: Mesenteric panniculitis INTERVENTIONS: Both MP patients were measured the levels of PGE-MUM. OUTCOMES: Both MP patients exhibited high levels of PGE-MUM before treatment. In one, the levels were sensitively correlated with clinical symptoms and serological markers on steroids. LESSONS: The study observations suggest the potential of PGE-MUM to reflect the disease activity of MP. To verify its use, more findings based on clinical studies should be accumulated. Wolters Kluwer Health 2017-12-22 /pmc/articles/PMC5758180/ /pubmed/29390478 http://dx.doi.org/10.1097/MD.0000000000009237 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4500
Mizuno, Shinta
Wakui, Masatoshi
Machida, Yujiro
Hosoe, Naoki
Hisamatsu, Tadakazu
Ishida, Takashi
Kameyama, Kaori
Naganuma, Makoto
Kanai, Takanori
Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report
title Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report
title_full Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report
title_fullStr Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report
title_full_unstemmed Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report
title_short Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report
title_sort increased levels of prostaglandin e-major urinary metabolite (pge-mum) in active mesenteric panniculitis patients: a case report
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758180/
https://www.ncbi.nlm.nih.gov/pubmed/29390478
http://dx.doi.org/10.1097/MD.0000000000009237
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