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Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients

Given discrepancies between methods for diagnosing hyposplenism, the purpose of this study was to evaluate the effect of the spleen size on the correlation between the methods, and to propose a model for improving the interpretation. Patients with renal allografts were included, in whom the spleen w...

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Autores principales: Araújo, Nordeval Cavalcante, Orlando, Margarida Maria Camões, Neves, Moises Bonifácio, Rioja, Suzimar Silveira, de Lucena, Stella Beatriz Gonçalves, Mandarim-de-Lacerda, Carlos Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758183/
https://www.ncbi.nlm.nih.gov/pubmed/29390481
http://dx.doi.org/10.1097/MD.0000000000009242
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author Araújo, Nordeval Cavalcante
Orlando, Margarida Maria Camões
Neves, Moises Bonifácio
Rioja, Suzimar Silveira
de Lucena, Stella Beatriz Gonçalves
Mandarim-de-Lacerda, Carlos Alberto
author_facet Araújo, Nordeval Cavalcante
Orlando, Margarida Maria Camões
Neves, Moises Bonifácio
Rioja, Suzimar Silveira
de Lucena, Stella Beatriz Gonçalves
Mandarim-de-Lacerda, Carlos Alberto
author_sort Araújo, Nordeval Cavalcante
collection PubMed
description Given discrepancies between methods for diagnosing hyposplenism, the purpose of this study was to evaluate the effect of the spleen size on the correlation between the methods, and to propose a model for improving the interpretation. Patients with renal allografts were included, in whom the spleen was assessed using Doppler ultrasound, scintiscan, and the presence of Howell-Jolly bodies (HJBs) in peripheral smears. In 35 subjects, scintiscan and HJBs were normal (Group 0); 20 had an abnormal result in both methods (Group 1); 34 had discordant results with HJBs present (Group 2); and 14 had discordant results with decreased spleen uptake (Group 3). There was no association between HJBs and scintiscan. The patients of Groups 1 and 2 had smaller spleens. The patients with smaller spleen had more hematological evidence of hyposplenism and exhibit smaller discrepancies between the methods than patients with larger spleen. The spleen can tip the balance from a normal to impaired function provided that the spleen size is below the critical mass required to maintain splenic function. A mild impairment of phagocytic function and slight dyserythropoiesis along with a small spleen would result in decreased take up of radiocolloid or the appearance of HJBs in blood smears.
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spelling pubmed-57581832018-01-29 Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients Araújo, Nordeval Cavalcante Orlando, Margarida Maria Camões Neves, Moises Bonifácio Rioja, Suzimar Silveira de Lucena, Stella Beatriz Gonçalves Mandarim-de-Lacerda, Carlos Alberto Medicine (Baltimore) 4100 Given discrepancies between methods for diagnosing hyposplenism, the purpose of this study was to evaluate the effect of the spleen size on the correlation between the methods, and to propose a model for improving the interpretation. Patients with renal allografts were included, in whom the spleen was assessed using Doppler ultrasound, scintiscan, and the presence of Howell-Jolly bodies (HJBs) in peripheral smears. In 35 subjects, scintiscan and HJBs were normal (Group 0); 20 had an abnormal result in both methods (Group 1); 34 had discordant results with HJBs present (Group 2); and 14 had discordant results with decreased spleen uptake (Group 3). There was no association between HJBs and scintiscan. The patients of Groups 1 and 2 had smaller spleens. The patients with smaller spleen had more hematological evidence of hyposplenism and exhibit smaller discrepancies between the methods than patients with larger spleen. The spleen can tip the balance from a normal to impaired function provided that the spleen size is below the critical mass required to maintain splenic function. A mild impairment of phagocytic function and slight dyserythropoiesis along with a small spleen would result in decreased take up of radiocolloid or the appearance of HJBs in blood smears. Wolters Kluwer Health 2017-12-22 /pmc/articles/PMC5758183/ /pubmed/29390481 http://dx.doi.org/10.1097/MD.0000000000009242 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4100
Araújo, Nordeval Cavalcante
Orlando, Margarida Maria Camões
Neves, Moises Bonifácio
Rioja, Suzimar Silveira
de Lucena, Stella Beatriz Gonçalves
Mandarim-de-Lacerda, Carlos Alberto
Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
title Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
title_full Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
title_fullStr Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
title_full_unstemmed Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
title_short Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
title_sort howell-jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758183/
https://www.ncbi.nlm.nih.gov/pubmed/29390481
http://dx.doi.org/10.1097/MD.0000000000009242
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