Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology

Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson’s disease (PD). Many putative substrates of parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization, particularly in vivo. Here, we show that synaptotagmin...

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Detalles Bibliográficos
Autores principales: Wang, Changhe, Kang, Xinjiang, Zhou, Li, Chai, Zuying, Wu, Qihui, Huang, Rong, Xu, Huadong, Hu, Meiqin, Sun, Xiaoxuan, Sun, Suhua, Li, Jie, Jiao, Ruiying, Zuo, Panli, Zheng, Lianghong, Yue, Zhenyu, Zhou, Zhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758517/
https://www.ncbi.nlm.nih.gov/pubmed/29311685
http://dx.doi.org/10.1038/s41467-017-02593-y

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