PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report

Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy...

Descripción completa

Detalles Bibliográficos
Autores principales: Azarpira, Negar, Safaie, Akbar, Monabati, Ahmad, Hosseinzadeh, Masudd, Noori, Sadat, Moini, Maryam, Rahimi, Alireza, Heidari, Tahereh, Rahsaz, Marjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758743/
https://www.ncbi.nlm.nih.gov/pubmed/29379600
_version_ 1783291052494422016
author Azarpira, Negar
Safaie, Akbar
Monabati, Ahmad
Hosseinzadeh, Masudd
Noori, Sadat
Moini, Maryam
Rahimi, Alireza
Heidari, Tahereh
Rahsaz, Marjan
author_facet Azarpira, Negar
Safaie, Akbar
Monabati, Ahmad
Hosseinzadeh, Masudd
Noori, Sadat
Moini, Maryam
Rahimi, Alireza
Heidari, Tahereh
Rahsaz, Marjan
author_sort Azarpira, Negar
collection PubMed
description Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and PAX5 positive. The patient responded to CHOP-based chemotherapy. This case illustrated an unusual presentation of primary Non Hodgkin lymphoma of esophagus.
format Online
Article
Text
id pubmed-5758743
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-57587432018-01-29 PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report Azarpira, Negar Safaie, Akbar Monabati, Ahmad Hosseinzadeh, Masudd Noori, Sadat Moini, Maryam Rahimi, Alireza Heidari, Tahereh Rahsaz, Marjan Gastroenterol Hepatol Bed Bench Case Report Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and PAX5 positive. The patient responded to CHOP-based chemotherapy. This case illustrated an unusual presentation of primary Non Hodgkin lymphoma of esophagus. Shaheed Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5758743/ /pubmed/29379600 Text en ©2017 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Azarpira, Negar
Safaie, Akbar
Monabati, Ahmad
Hosseinzadeh, Masudd
Noori, Sadat
Moini, Maryam
Rahimi, Alireza
Heidari, Tahereh
Rahsaz, Marjan
PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
title PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
title_full PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
title_fullStr PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
title_full_unstemmed PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
title_short PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
title_sort pax-5 positive anaplastic large cell lymphoma presenting by dysphagia; a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758743/
https://www.ncbi.nlm.nih.gov/pubmed/29379600
work_keys_str_mv AT azarpiranegar pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT safaieakbar pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT monabatiahmad pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT hosseinzadehmasudd pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT noorisadat pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT moinimaryam pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT rahimialireza pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT heidaritahereh pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport
AT rahsazmarjan pax5positiveanaplasticlargecelllymphomapresentingbydysphagiaacasereport

Ejemplares similares