Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

Intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of Alzheimer’s disease (AD), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded β-sheet rich aggregates. Therefore, inhibiting the aggregation cascade or disassembling the...

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Detalles Bibliográficos
Autores principales: KrishnaKumar, V. Guru, Paul, Ashim, Gazit, Ehud, Segal, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758761/
https://www.ncbi.nlm.nih.gov/pubmed/29311706
http://dx.doi.org/10.1038/s41598-017-18443-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758761/
https://www.ncbi.nlm.nih.gov/pubmed/29311706
http://dx.doi.org/10.1038/s41598-017-18443-2

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