HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hT...

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Detalles Bibliográficos
Autores principales: Yan, TingDong, Ooi, Wen Fong, Qamra, Aditi, Cheung, Alice, Ma, DongLiang, Sundaram, Gopinath Meenakshi, Xu, Chang, Xing, Manjie, Poon, LaiFong, Wang, Jing, Loh, Yan Ping, Ho, Jess Hui Jie, Ng, Joscelyn Jun Quan, Ramlee, Muhammad Khairul, Aswad, Luay, Rozen, Steve G., Ghosh, Sujoy, Bard, Frederic A., Sampath, Prabha, Tergaonkar, Vinay, Davies, James O. J., Hughes, Jim R., Goh, Eyleen, Bi, Xuezhi, Fullwood, Melissa Jane, Tan, Patrick, Li, Shang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758779/
https://www.ncbi.nlm.nih.gov/pubmed/29311615
http://dx.doi.org/10.1038/s41467-017-02601-1

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