A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature

The autoimmune disorder Aicardi-Goutières syndrome (AGS) is characterized by a constitutive type I interferon response. SAMHD1 possesses both dNTPase and RNase activities and mutations in SAMHD1 cause AGS; however, how SAMHD1-deficiency causes the type I interferon response in patients with AGS rema...

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Detalles Bibliográficos
Autores principales: Oh, Changhoon, Ryoo, Jeongmin, Park, Kiwon, Kim, Baek, Daly, Michele B., Cho, DongYeon, Ahn, Kwangseog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758801/
https://www.ncbi.nlm.nih.gov/pubmed/29311560
http://dx.doi.org/10.1038/s41598-017-18308-8

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