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DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma

Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9...

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Detalles Bibliográficos
Autores principales:	Mizuno, Yuki, Shimada, Shu, Akiyama, Yoshimitsu, Watanabe, Shuichi, Aida, Tomomi, Ogawa, Kosuke, Ono, Hiroaki, Mitsunori, Yusuke, Ban, Daisuke, Kudo, Atsushi, Arii, Shigeki, Yamaoka, Shoji, Tanabe, Minoru, Tanaka, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758822/ https://www.ncbi.nlm.nih.gov/pubmed/29311600 http://dx.doi.org/10.1038/s41598-017-18323-9

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