Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin

Metastatic tumor cells engage the local tumor microenvironment and activate specific pro-survival mechanisms to thrive and progress in the harsh bone marrow niche. Here we show that the major contributors to the survival of carcinoma cells that have colonized the bone marrow are the adipocyte-induce...

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Detalles Bibliográficos
Autores principales: Herroon, Mackenzie K., Rajagurubandara, Erandi, Diedrich, Jonathan D., Heath, Elisabeth I., Podgorski, Izabela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758829/
https://www.ncbi.nlm.nih.gov/pubmed/29311669
http://dx.doi.org/10.1038/s41598-017-17800-5

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