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Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides

This manuscript reports the molecular basis for double-stranded DNA (dsDNA) binding of hairpin polyamides incorporating a 5-alkyl thiazole (Nt) unit. Hairpin polyamides containing an N-terminal Nt unit induce higher melting stabilisation of target dsDNA sequences relative to an archetypical hairpin...

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Detalles Bibliográficos
Autores principales:	Padroni, Giacomo, Parkinson, John A, Fox, Keith R, Burley, Glenn A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758887/ https://www.ncbi.nlm.nih.gov/pubmed/29194552 http://dx.doi.org/10.1093/nar/gkx1211

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