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A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation

RNA polymerase (RNAP) is a major target of gene regulation. Thermus thermophilus bacteriophage P23–45 encodes two RNAP binding proteins, gp39 and gp76, which shut off host gene transcription while allowing orderly transcription of phage genes. We previously reported the structure of the T. thermophi...

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Detalles Bibliográficos
Autores principales:	Ooi, Wei-Yang, Murayama, Yuko, Mekler, Vladimir, Minakhin, Leonid, Severinov, Konstantin, Yokoyama, Shigeyuki, Sekine, Shun-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758890/ https://www.ncbi.nlm.nih.gov/pubmed/29165680 http://dx.doi.org/10.1093/nar/gkx1162

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