Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain

Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound to the H3K27ac peptide reveals that the sequence C-...

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Detalles Bibliográficos
Autores principales: Klein, Brianna J, Ahmad, Salar, Vann, Kendra R, Andrews, Forest H, Mayo, Zachary A, Bourriquen, Gaelle, Bridgers, Joseph B, Zhang, Jinyong, Strahl, Brian D, Côté, Jacques, Kutateladze, Tatiana G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758897/
https://www.ncbi.nlm.nih.gov/pubmed/29145630
http://dx.doi.org/10.1093/nar/gkx1151

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