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Detection of expanded RNA repeats using thermostable group II intron reverse transcriptase

Cellular accumulation of repetitive RNA occurs in several dominantly-inherited genetic disorders. Expanded CUG, CCUG or GGGGCC repeats are expressed in myotonic dystrophy type 1 (DM1), myotonic dystrophy type 2 (DM2), or familial amyotrophic lateral sclerosis, respectively. Expanded repeat RNAs (ER-...

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Detalles Bibliográficos
Autores principales:	Carrell, Samuel T, Tang, Zhenzhi, Mohr, Sabine, Lambowitz, Alan M, Thornton, Charles A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758912/ https://www.ncbi.nlm.nih.gov/pubmed/29036654 http://dx.doi.org/10.1093/nar/gkx867

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